Objective:To explore the clinical efficacy of total knee arthroplasty(TKA)in elderly patients with diabetes.Methods:A total of 120 patients aged 65 and above who underwent unilateral total knee arthroplasty at Yichang Central People's Hospital from January 2022 to January 2024 were enrolled.All of the patients were divide into the observation group with diabetes(n=56)and the control group without diabetes(n=64)based on whether they had diabetes.The baseline data,surgery-related indexes,perioperative complications and postoperative functional scores of the two groups were compared.Results:The incidence of hypertension(85.71%vs 37.50%)and cardiac function abnormalities(69.64%vs 42.19%)in the observation group was significantly higher than those in the control group.Compared to the control group,the preoperative hospital stay[(6.23±3.12)days vs(3.61±3.43)days]and total hospital stay[(20.83±7.52)days vs(17.81±6.92)days]in the observation group were significantly longer,and the intraoperative blood loss[(285.13±75.23)mL vs(245.12±68.13)mL]was significantly higher.Among the perioperative complications of the two groups,the incidence of delayed wound healing in the observation group was significantly higher than in the control group(19.64%vs 4.69%).The SF-36 physical function score of the observation group at 6 months postoperatively was significantly lower than the control group[(75.32±12.63)vs(81.52±11.82)[.Conclusion:TKA in elderly diabetic patients is safe and feasible,while there exists a higher risk of delayed wound healing.Preoperative blood sugar should be actively controlled and perioperative management optimized to improve patient outcomes.