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危重症患者血糖管理研究进展

Progress in Glycaemic Management in Critically Patients

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危重症患者入院时由于机体处于应激状态,大量细胞因子释放和神经内分泌紊乱常常引起应激性高血糖(SIH),造成患者水、电解质和酸碱平衡紊乱,感染风险增加.临床上首选持续静脉输注胰岛素控制血糖,然而不当使用胰岛素治疗可导致低血糖.患者血糖波动增加血糖变异性(GV),加重氧化应激诱导炎症反应,使危重症患者的 自身免疫调节系统和血管内皮功能产生破坏,加重患者病情,威胁患者生命.综上所述,危重症患者进行血糖管理至关重要.本篇论文主要探讨了血糖水平对危重症患者预后的影响,阐述了其发生机制,并总结了血糖管理的最新研究成果,旨在为危重症患者的血糖管理提供参考依据.
When patients are admitted to the hospital in critical condition,their bodies undergo stress which leads to the release of a large number of cytokines and neuroendocrine disorders.This often causes stress-induced hyperglycemia(SIH).SIH can result in disturbances in water,electrolyte,and acid-base balance,as well as an increased risk of infection.Continuous intravenous insulin infusion is commonly recommended in clinical practice to regulate blood glucose levels.However,improper use of insulin therapy may lead to hypoglycemia.Blood sugar fluctuations in patients can increase glycemic variability(GV)and exacerbate oxidative stress-induced inflammatory responses.This can cause damage to the immune system and vascular endothelial function in critically patients,posing a threat to their lives.In summary,glycemic management is crucial for critically patients.This review summarizes the latest advances in glycemic management in critically patients,mainly from the impact and mechanism of glycaemia on the prognosis of critically patients,and glycaemic management measures.The objective is to provide a reference for the management of blood glucose in critically patients.

critical patientsblood glucose managementhyperglycemiahypoglycemiaglycemic variability(GV)

刘延雯、高静

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新疆医科大学第五附属医院 内分泌科,新疆乌鲁木齐 830011

危重症患者 血糖管理 高血糖 低血糖 血糖变异性

2024

巴楚医学
三峡大学

巴楚医学

ISSN:2096-6113
年,卷(期):2024.7(4)