Taking the fruit body of Hypsizygus marmoreus as the test meterial,the transcriptome changes of post harvest Hypsizygus marmoreus fruiting bodies during storage were studied by using high-throughput sequencing technology,in order to provide reference for revealing post harvest quality changes and inhibiting fruiting body browning.The results showed that 3 659 differentially expressed genes were obtained on the 10th day compared to the 0th day,included 1 707 upregulated genes and 1 952 downregulated genes under storage conditions of 4 ℃.Moreover,on the 10th day after 1-MCP treatment,compared to the 0th day,4 142 differentially expressed genes were obtained,included 2 122 upregulated genes and 2 020 downregulated genes.Three differentially expressed laccase genes and one differentially expressed peroxidase gene were screened,namely LAC1,LAC2,LAC4,and POD2.These genes might be closely related to the occurrence of browning in fruiting bodies.