Coagulation Abnormalities in Children with Cyanotic and Non-cyanotic Congenital Heart Disease
Objective Coagulation abnormalities are a serious complication and the cause of death in children with uncorrected congenital heart disease.The aim of this study is to evaluate the prevalence and identify related factors of coagulation abnormalities in children with congenital heart disease,and to further compare the coagulation abnormalities between cyanotic and non-cyanotic groups of children.Methods A total of 650 children with uncorrected congenital heart disease,including 245 cases of cyanotic congenital heart disease and 405 cases of non-cyanotic congenital heart disease,who were treated at Fuwai Hospital of the Chinese Academy of Medical Sciences from January,2016 to December,2019,were included for the study.We collected the whole blood cell count and coagulation routine test results of children with cyanotic and non-cyanotic congenital heart disease,and used platelet count,prothrombin time, activated partial thromboplastin time,D-dimer,fibrinogen,and fibrinogen degradation product test values to determine whether coagulation abnormalities had occurred.Results The incidence of coagulation abnormalities in children with cyanotic and non-cyanotic congenital heart disease were 60.4％ and 44.7％,respectively.The correlations between the number of red blood cells,hemoglobin concentration,hematocrit,and distribution width of red blood cell volume with platelet count, prothrombin time,and activated partial prothrombin time were statistically significant (P<0.05). Conclusion Uncorrected coagulation abnormalities are common in children with congenital heart disease.When compared with children with non-cyanotic congenital heart disease,children with cyanotic congenital heart disease are more prone to have coagulation abnormalities.
万方数据
维普
