Objective To evaluate the value of peripheral blood cell ratio as a clinical stage of dermatomyositis (DM),and to explore the diagnostic and predictive value of blood cell ratio in DM patients with different complications.Methods The blood cell test results and clinical data of 183 patients with dermatomyositis (disease group)and 149 healthy subjects (control group)hospitalized in the Rheumatology Department of the 1st Medical Center of PLA General Hospital were collected for the statistical analysis.Blood cell ratio between DM patients and control group was compared. ROC curve and logistic regression method were used to evaluate the diagnostic efficiency and risk factors of blood cell ratio in DM and its complications.Results The ratio of monocyte to lymphocyte (MLR),neutrophil to lymphocyte (NLR)and platelet-to-lymphocyte (PLR)in DM patients were significantly higher than those in the control group (P<0.001).The prevalence of interstitial lung disease (ILD)and myocardial involvement (MI)in female DM patients was significantly higher than that in male DM patients (P<0.001).AUCs for blood cell ratio diagnosis of DM were 0.868 (MLR), 0.910 (NLR)and 0.784 (PLR),respectively.MLR of DM patients with ILD was significantly higher than that of DM patients without ILD (P=0.024).NLR of DM patients with MI was significantly higher than that of patients without MI (P=0.023).There was no significant difference in PLR among DM patients with ILD and MI (P>0.05).AUC for MLR differential diagnosis of ILD was 0.598 (P=0.024,95％CI 0.515-0.682);AUC for NLR differential diagnosis MI was 0.631 (P=0.023, 95％ CI 0.522-0.740).Univariate and multivariate regression analysis showed that MLR was an independent risk factor for ILD in DM patients (P=0.003,OR=9.400,95％ CI 2.120-41.678).NLR and age were risk factors for MI in DM patients (NLR OR=1.036,95％ CI=1.008-1.064,P=0.012;Age OR=1.104,95％ CI 1.003-1.215,P=0.043).Conclusion Blood cell ratio is a simple,convenient, economical and accurate diagnostic and predictive marker for DM patients.MLR and NLR are independent risk factors for ILD and MI in DM patients,respectively,and have predictive value for the diagnosis of DM.
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