摘要
目的 通过研究不同肿瘤标志物水平、不同病理状态下胃癌患者的预后生存情况,找到影响患者生存预后的危险因素.方法 收集2018年12月至2021年1月在解放军总医院第一医学中心行手术治疗的164例胃癌患者临床资料,并随访患者生存情况,分析影响胃癌患者生存的风险因素.结果 生存时间≤2年的胃癌患者血清CYFRA21-1、PGⅡ水平明显高于生存时间>2年组,差异具有统计学意义(P=0.002、0.023).胃癌患者在CA72-4≤10U/mL、CYFRA21-1≤4.0ng/mL、TNM分期为Ⅰ+Ⅱ期、Lauren分型为肠型、非印戒细胞癌中1、2、3年生存率较高,在CA72-4>10U/mL、CYFRA21-1>4.0ng/mL、TNM分期为Ⅲ+Ⅳ期、Lauren分型为弥散型、印戒细胞癌中生存率较低,差异具有统计学意义(P=0.0001、0.0007、<0.0001、<0.0001、0.0002).血清CA72-4、CYFRA21-1水平、印戒细胞癌、TNM分期是影响胃癌患者生存的风险因素(P=0.001、<0.001、<0.001、<0.001).结论 血清高CA72-4、CYFRA21-1水平、印戒细胞癌、TNM分期较晚是胃癌患者生存预后的风险因素.
Abstract
Objective In the current study,by studying the prognosis and survival of patients with gastric cancer under different levels of tumor markers and different pathological states,the risk factors affecting the survival and prognosis of patients were identified.Methods The clinical data of 164 patients with gastric cancer who underwent surgical treatment in the First Medical Center of the PLA General Hospital from December, 2018 to January,2021 were collected,and the survival conditions of these patients were followed up to analyze the risk factors affecting the survival of patients with gastric cancer.Results Serum CYFRA21-1 and PG-Ⅱ levels of gastric cancer patients with survival time ≤2 years were significantly higher than those of patients with survival time >2 years (P=0.002,0.023).1,2,and 3-year survival rates of gastric cancer patients were higher in CA72-4≤10U/mL,CYFRA21-1≤4.0ng/mL,TNM stage Ⅰ+Ⅱ,Lauren's intestinal type,and non-signet-ring cell carcinoma group.For patients with CA72-4>10U/mL,CYFRA21-1>4.0ng/mL,TNM stage Ⅲ+Ⅳ,and Lauren's type which was diffuse type,signet ring cell carcinoma was lower for the survival rates,and the differences were statistically significant (P=0.0001,0.0007,<0.0001,<0.0001,0.0002).Serum CA72-4,CYFRA21-1 levels,signet ring cell carcinoma and TNM stage were risk factors affecting the survival of patients with gastric cancer (P=0.001,<0.001,<0.001,<0.001).Conclusion High serum CA72-4,CYFRA21-1 levels,signet ring cell carcinoma and late TNM staging are risk factors for survival and prognosis in patients with gastric cancer.
维普
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