A Correlation Analysis and Methodological Evaluation of Clinical Parameters in Patients with Benign Prostatic Hyperplasia
Objective To evaluate the correlation between prostate volume,age,serum total prostate specific antigen(TPSA),serum free prostate specific antigen(FPSA),and prostate-specific antigen density (PSAD) in patients with benign prostatic hyperplasia(BPH),and to study the accuracy of predicting prostate volume PV size by patient age.To further study the feasibility and practicability of detecting serum TPSA and FPSA by latex immunoturbidimetry compared with electrochemical luminescence method.Methods Clinical data of 172 patients were collected for the statistical analysis,and the correlation between age,prostate volume, TPSA,FPSA and PSAD was summarized.The accuracy of serum TPSA and FPSA in predicting prostate volume was evaluated by receiver characteristic ROC curve.Serum TPSA and FPSA were detected by two methods at the same time,and their correlation,deviation analysis and positive and negative coincidence rate were compared.Results TPSA,FPSA and PV increased with increasing age (r=0.318,0.325,0.511,all P<0.01).TPSA and FPSA also increased with increasing PV (r=0.279,0.368,all P<0.01).Compared with TPSA,FPSA was more strongly correlated with patient age and PV.When TPSA level was<4ng/mL, AUCs predicted by TPSA were 0.621,0.708 and 0.913 for prostate volume of 30-49mL,50-79mL and>80mL, and the optimal critical values were 0.7ng/mL,1.98ng/mL and 2.37ng/mL,respectively.AUCs predicted by FPSA were 0.682,0.711 and 0.832,and the optimal critical values were 0.37ng/mL,0.56ng/mL and 0.81ng/mL,respectively.TPSA and FPSA were well correlated with latex immunoturbidimetry (r=0.986, 0.975,P<0.01).The results of TPSA and FPSA measured by the two methods were in a good agreement. The positive coincidence rate,negative coincidence rate and total coincidence rate were 98.63％ and 90.54％,93.94％ and 96.94％,96.51％ and 94.18％,respectively,and Kappa values were 0.930 and 0.850 (P<0.01 ).Its precision,linear range and reference interval verification all met the standards. Conclusion There is a significant correlation between patient age,prostate volume,TPSA level and FPSA level.Serum TPSA and FPSA can be used as simple and feasible factors to predict PV independently in clinical practice,and FPSA has a higher accuracy in predicting PV.Latex immunoturbidimetry is in a good agreement with electrochemiluminescence.Latex immunoturbidimetry can be used as a recommended method for detecting TPSA and FPSA levels.
BPHProstate specific antigenFree prostate specific antigenAgeProstate volumeLatex immunoturbidimetryElectrochemical luminescence method
万方数据
维普
