A Correlation Study Between Sarcopenia and Severity of Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients
Objective To explore the relationship between sarcopenia and different stages of diabetic kidney disease (DKD)in patients with type 2 diabetes mellitus (T2DM),as well as related factors.Methods A total of 238 T2DM patients who visited the Endocrinology Department of the First Affiliated Hospital of Anhui Medical University from July,2020 to March,2022 were selected for the study.According to the urinary albumin-to-creatinine ratio (UACR)and renal function,these patients were divided into the normal urine protein group,the microalbuminuria group,the macroalbuminuria group,and the end-stage renal disease group.Clinical information was collected from all subjects,and physical examinations,laboratory tests,and assessments of sarcopenia were performed.General clinical data and laboratory results among the four groups of patients were compared using t-tests or variance tests,and the relationship between DKD and sarcopenia in T2DM patients was explored using univariate and multivariate logistic regression analysis.Results As the degree of DKD increased,the proportion of sarcopenia increased significantly.The analysis of physical functions showed that the more severe the DKD,the lower the SPPB score.However,there was no significant difference in muscle mass or muscle strength,and the severity of DKD was also related to age,duration of disease,Homa IR (CP),as well as the proportion of diabetic peripheral neuropathy, diabetic retinopathy and hypertension.In addition,univariate and multivariate logistic regression analysis showed that age,Homa IR (CP),and diabetic kidney disease were independent risk factors for both sarcopenia and decreased physical function in T2DM patients,while body mass index was an independent protective factor for sarcopenia in T2DM patients.Conclusion With the aggravation of DKD,the proportion of T2DM patients with sarcopenia significantly increases.DKD is an independent risk factor for sarcopenia.Therefore,an actively controlling of blood sugar in T2DM patients,as well as preventing and treating chronic complications,is conducive to the early prevention of sarcopenia.
Type 2 diabetes mellitusDiabetic kidney diseaseSarcopenia
万方数据
维普
