Prognostic Value of Individual and Combined NLR and TyG Index for Disease Severity in COVID-19 Patients
Objective To explore the relationship between NLR combined with the TyG index and the severity and prognosis of COVID-19.Methods The clinical data of 87 COVID-19 patients who were hospitalized and diagnosed in the First Hospital of Shanxi Medical University from December 1,2022 to December 31,2023 were retrospectively analyzed.According to the severity of the disease,these patients were divided into the mild case group (n=56 ) and severe case group (n=31 ).The general conditions, chronic disease comorbidities,blood routine indicators,biochemical indicators,NLR and TyG index of these two groups were compared.After grouping according to the median NLR and TyG index,outcomes,respiratory support methods and disease severity were compared.Risk factors influencing COVID-19 severity were identified using logistic regression.AUC values of NLR,TyG index and their combination in predicting the proportion of COVID-19 patients progressing to severe disease were evaluated through the receiver operating characteristic curve (ROC).Results The NLR and TyG index of the severe case group were significantly higher than those of the mild case group (NLR:P<0.001,TyG:P=0.028).When dividing the study subjects into 4 groups based on the median NLR and TyG index,COVID-19 patients in the high NLR and TyG groups had more severe illness (P<0.001)and were more likely to require ventilators for breathing assistance (P=0.037).After adjusting for multiple confounding factors,NLR remained as an independent factor affecting the severity of COVID-19 (P=0.001,OR=1.164,95％ CI 1.066-1.271).The area under the curve (AUC)for NLR and TyG index in predicting the severity of COVID-19 infection were 0.759 and 0.643,respectively.Combining the two predictions resulted in a higher AUC (AUC=0.777)compared to individual predictions.Conclusion NLR and TyG index are closely related to the severity of COVID-19 infection,and are expected to be used as predictors of severe cases.The combination of these two markers has a higher predictive value and may help to formulate the early-stage individualized treatment plans.
Coronavirus disease-19 (COVID-19)Neutrophil-to-lymphocyte ratio (NLR)Triglyceride-glucose index(TyG index)
万方数据
维普
