A Meta-analysis of the Diagnostic Value of Blood Exosome-derived MicroRNAs for Rheumatoid Arthritis
Objective To evaluate the performance of blood exosome-derived miRNAs in the early diagnosis of rheumatoid arthritis by using a meta-analysis method.Methods Literature on exosomes in the diagnosis of rheumatoid arthritis was collected from PubMed,Web of science,Embase,Cochrane Library,CNKI,and other databases.We used QUADS-2 to assess risk and bias among all enrolled studies.A meta-analysis was performed using Stata 16.0,RevMan 5.3,and Meta-Disc 1.4 software to calculate the combined SEN,SPE, PLR,NLR,DOR.The heterogeneity and publication bias were analyzed using SROC and AUC methods. Results A total of 2,698 articles were retrieved and six articles were included after screening process,which contained eighteen miRNAs.The random-effects model was used to combine the effect sizes and results were as following:the combined sensitivity of 0.80 (95％ CI 0.73-0.86),the specificity of 0.77 (95％ CI 0.73-0.80),PLR of 3.5 (95％CI 2.9-4.2),NLR of 0.26 (95％CI 0.18-0.36),DOR of 14 (95％CI 8-22),and AUC=0.82 (95％ CI 0.79-0.85).Conclusion Blood exosome-derived miRNAs have high diagnostic values and significance for RA and can be used as a marker for the diagnosis of RA,but due to the limitations of the current quantity and quality of the literature,more clinical studies are needed for future validation.
万方数据
维普
