Changes of Serum S100B Protein,NT-3 and GFAP Levels in Patients with First-episode Schizophrenia and Their Relationships with Cognitive Function and Prognosis
Objective To investigate changes of serum S100 calcium-binding protein B (S100B),neurotrophic factor 3 (NT-3)and glial fibrillary acidic protein (GFAP)levels in patients with first-episode schizophrenia and their relationships with cognitive function and prognosis.Methods The clinical data of 100 patients with first-episode schizophrenia who were diagnosed and treated in our hospital from February, 2019 to February,2022 were retrospectively analyzed.These patients were selected as the observation group.The selected patients were further divided into the mild cognitive impairment group (n=42,MCCB≥200 points) and severe cognitive impairment group (n=58,MCCB score<200 points).Patients were also divided into prognosis groups according to the gross rating scale (GAS):score good group (n=72,GAS≥61 points)and poor prognosis group (n=28,GAS<61 points),while another 50 healthy subjects during the same period were selected as the control group.The differences in serum S100B protein,NT-3 and GFAP levels between different groups were compared,and their relationships with cognitive function and prognosis was analyzed. Results Serum levels of S100B protein and GFAP in the observation group were higher than those in the control group,and the serum NT-3 level was lower than that in the control group (P<0.05).Levels of serum S100B protein and GFAP in the mild cognitive impairment group were lower than those in the severe cognitive impairment group,while the serum NT-3 level was higher than that in the severe cognitive impairment group (P<0.05).Serum levels of S100B protein and GFAP in the good prognosis group were lower than those in the poor prognosis group,while the serum NT-3 level was higher than that in the poor prognosis group (P<0.05).Pearson correlation test showed that serum S100B protein and GFAP levels were negatively correlated with MCCB score (r=-0.288,-0.267,P<0.05 ),while serum NT-3 level was positively correlated with MCCB score (r=0.380,P<0.05).ROC curve analysis showed that serum S100B protein,NT-3,and GFAP levels had extremely high values in predicting poor prognosis in patients with first-episode schizophrenia.Conclusion The increase of serum S100B protein and GFAP level and the decrease of serum NT-3 level in patients with first-episode schizophrenia are correlated with cognitive dysfunction, which can be helpful for the early diagnosis of the disease.The above three indicators are extremely important in predicting the poor prognosis of patients and can be used to assess the prognosis.
万方数据
维普
