An Analysis of Transfusion Efficacy and Influencing Factors in Patients with Multiple Platelet Transfusions
Objective To analyze the efficacy of multiple platelet transfusions and explore the possible influencing factors.Methods 100 patients with multiple platelet transfusions (three times or more)who stayed in hospital from January to December in 2020 were selected as the objects of study.The effect of platelet transfusion was determined according to CCI and PPR values of patients combined with clinical bleeding symptoms.The single factor analysis was used to explore whether the results of platelet antibody screening, the number of platelet transfusion,the patients gender,blood type,anti-allergic drugs,splenomegaly, radiotherapy and chemotherapy,adverse reactions,and hepatitis B virus infection affected the efficacy of patients with multiple platelet transfusions.Based on the results of the univariate analysis,a multivariate logistic regression analysis was performed to determine the risk factors for platelet refractoriness (PTR)in patients with multiple platelet transfusions.Results A total of 322 platelet transfusions in 100 patients, including 272 effective platelet transfusions (84.47％)and 50 ineffective platelet infusions (15.53％).The results of univariate analysis indicated that the effect of platelet transfusion was related with platelet antibody,sex,anti-allergic drugs,splenic size,adverse transfusion reactions,and hepatitis B virus infection (P<0.05),but not correlated with patient age,blood type,radiotherapy and chemotherapy,transfusion times,and bacterial culture (P>0.05).The result of the multivariate logistic regression analysis showed that female gender,positive platelet antibody,splenomegaly,adverse blood transfusion reactions,and HBV infection were the risk factors for ineffective platelet transfusion (OR>1,P<0.05).The application of allergic drugs before infusion could reduce the inefficiency of platelet transfusion (OR<1,P<0.05). Conclusion Gender,splenomegaly,adverse reactions of blood transfusion,hepatitis B virus infection and positive platelet antibody are the risk factors for multiple platelet transfusions.The application of antiallergic drugs can reduce the ineffective infusion of patients (possibly for some special populations)to some extent. For patients needed for multiple platelet transfusions,before platelet transfusion,clinicians should intervene in advance according to their own conditions,and then perform platelet transfusion after symptomatic treatment,so as to improve the efficacy of transfusion and save blood resources.
万方数据
维普
