The Correlation of Serum GDF-15,TGF-β1 and HbA1c with Perioperative Myocardial Injury in Patients with Coronary Heart Disease Undergoing PCI
Obj ective To explore the correlation between serum growth differentiation factor 15 (GDF-15 ), transforming growth faction-β1 (TGF-β1 ) and glycosylated hemoglobin (HbA1 c ) and perioperative myocardial injury (PMI ) in patients with coronary heart disease undergoing percutaneous coronary intervention (PCI).Methods 108 patients with coronary heart disease and 53 healthy subjects with physical examination from January,2020 to January 2023 were selected as the study subjects.According to the PMI occurrence during perioperative PCI,patients with coronary heart disease were divided into PMI group and non-PMI group.Serum GDF-15,TGF-β1,HbA1c and cardiac troponin T (cTnT )levels were compared between CHD group and the control group and also between PMI group and non-PMI group.The correlation between serum indicators and cTnT level was analyzed,and the clinical prediction value of combined detection of serum GDF-15,TGF-β1 and HbA1c on PMI was analyzed.Results The levels of serum GDF-15, TGF-β1 ,HbA1 c and cTnT in the coronary heart disease group were higher than those in the control group (P<0.05).Serum GDF-15,TGF-β1 and HbA1c levels in PMI group before and after surgery were higher than those in non-PMI group,and the cTnT level after surgery was higher than that in non-PMI group (P<0.05).The differences of serum GDF-15,TGF-β1,HbA1c and cTnT before and after surgery were higher in PMI group than those in non-PMI group (P<0.05).Serum GDF-15,TGF-β1 and HbA1c levels were positively correlated with cTnT level (r=0.527,0.356,0.419,P<0.05).The AUC value of combined detection of serum indicators (0.960)was higher than that of single-marker detection of serum GDF-15 (0.814),TGF-β1 (0.848)or HbA1c (0.889)(P<0.05).Conclusion The levels of serum GDF-15,TGF-β1 and HbA1c in patients with coronary heart disease undergoing PCI are related to the degree of PMI,and the combined detection of all indicators has a predictive value on PMI.
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