Influences of Intra-articular Injection of Tumor Necrosis Factor Receptor Antibody Fusion Protein on Joint Effusion,Knee Joint Function and ACPA Level in Patients with Refractory Rheumatoid Arthritis
Objective To investigate the influences of intra-articular injection of tumor necrosis factor receptor antibody fusion protein (rhTNFR:Fc,etanercept)on joint effusion,knee joint function and anti-citrullinated peptide antibody (ACPA)level in patients with refractory rheumatoid arthritis (RA).Methods RA patients with repeated knee joint effusion in our hospital were selected and divided into the control group and research group for the current study.Patients in the control group were given conventional basic treatment such as methotrexate tablets,while the research group were injected with rhTNFR:Fc into the joint cavity on the basis of the control group.The changes in joint effusion,knee joint function and ACPA level in these two groups after treatment were observed. Results The effective rate of treatment in the study group was higher than that in the control group (P<0.05).After treatment,the joint effusion depth and synovial thickness in the study group were lower than those in the control group (P<0.05);VAS score was lower than that of the control group (P<0.05);Lysholm knee function score was higher than that of the control group (P<0.05);Levels of ESR,CRP and ACPA in the control group were lower than those in the control group (P<0.05).There was no statistically significant difference in the incidence rate of adverse reactions between the two groups (P>0.05).Conclusion Intra-articular injection of rhTNFR:Fc in refractory RA patients has significant curative effect:it can reduce joint effusion,improve knee joint function, and delay the development process of the disease.
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