The Study of the Level and Clinical Significance of IGF-1 in Elderly Hypertensive Patients with Dementia
Objective To investigate the level and clinical significance of insulin-like growth factor-1 (IGF-1 ) in elderly hypertensive patients with dementia.Methods Elderly hypertensive patients admitted to our hospital from January,2021 to December,2022 were divided into two study groups:elderly hypertensive patients with dementia and elderly hypertensive patients without dementia. During the same period,elderly outpatients without hypertension or dementia were selected as the control group.We then retrospectively analyzed the correlation and significance between IGF-1 level and senile hypertension and dementia in these three groups.Results (1 )IGF-1 levels in elderly hypertensive patients with dementia were significantly lower than those in elderly hypertensive patients without dementia (respectively:70.3±38.5μg/L,88.7±26.2μg/L)(P<0.05);(2)IGF-1 levels in elderly hypertensive patients with dementia and elderly hypertensive patients without dementia were significantly lower than those in the control group (111.3 ±40.1μg/L)(both P<0.05);(3)Multivariate logistic regression analysis showed that IGF-1,hypertension history,left ventricular posterior wall thickness, and interventricular septal thickness were risk factors for hypertension and dementia in the elderly (OR>1,P<0.05),while gender,age,fasting blood glucose,TC,HDL-C,LDL-C,TG,hs-CRP were not (OR<1,P<0.05);(4)ROC curve analysis of the correlation between IGF-1 levels and elderly hypertension with dementia showed that the area under the ROC curve (AUC)was 0.889 (95％ CI 0.823-0.955,P<0.05).When IGF-1 was 93.5μg/L, the sensitivity for diagnosing elderly hypertension with dementia in this group of cases was 0.927 and the specificity was 0.711.Conclusion The level of IGF-1 in elderly hypertensive patients is significantly lower than that in non-hypertensive individuals,while it decreases further in elderly hypertensive patients with dementia,with significant difference,suggesting that both hypertension and dementia are important factors leading to the decrease of IGF-1 expression.Decreased IGF-1 ,hypertension history,increased left ventricular posterior wall thickness and interventricular septal thickness could be risk factors for hypertension and dementia in the elderly.The decreased IGF-1 level has a good diagnostic value for hypertension with dementia in the elderly.
万方数据
维普
