A Study of the Diagnostic Value of Pregnancy-associated Protein A in Atrial Fibrillation and Its Correlation with the Risk of Stroke
Objective To explore the diagnostic value of pregnancy-associated plasma protein A (PAPP-A)in atrial fibrillation,and to further investigate the relationship between PAPP-A and the risk scoring system (CHA2 DS2-VASc scores)for stroke in atrial fibrillation.Methods One hundred-one patients with atrial fibrillation (AF)who were hospitalized in Yongzhou Central Hospital from January,2021 to December, 2022 were enrolled as the AF group.According to the medical history,these patients were further divided into the paroxysmal atrial fibrillation (PaAF)group (n=57)and persistent atrial fibrillation (PeAF)group (n=44).In addition,112 healthy subjects were selected as the control group.Serum levels of PAPP-A were measured in all groups,and CHA2 DS2-VASc scores were calculated in AF group.ROC curves were drawn and the sensitivity and specificity were calculated to evaluate the diagnosis value.Results Serum levels of PAPP-A in AF group were significantly higher than those in the control group (P<0.05).There was no statistically significant difference in the subgroup analysis of age (P>0.05).Furthermore,serum levels of PAPP-A in PeAF group was significantly higher than those in PaAF group (P<0.05).The area under ROC curve,sensitivity and specificity of PAPP-A in the diagnosis of atrial fibrillation were 0.802,60.4％ and 83. 9％,respectively.Spearman correlation analysis showed a positive correlation between serum levels of PAPP-A and the CHA2 DS2-VASc scores (r=0.403,P<0.001).Conclusion PAPP-A has certain diagnostic value for atrial fibrillation.Serum levels of PAPP-A are related to the risk of stroke in patients with atrial fibrillation.
万方数据
维普
