The Value of Serum FGF19 and GDF15 in Evaluating the Prognosis of Patients with Liver Cancer Undergoing Interventional Therapy
Objective To investigate the prognostic value of serum fibroblast growth factor 19(FGF19)and growth differentiation factor 15(GDF15)in patients with liver cancer undergoing interventional therapy.Methods A total of 78 patients with primary liver cancer who received interventional therapy in our hospital from May,2019 to May,2022 were selected for the study.These patients were grouped into a recurrent group(20 cases)and non-recurrent group(58 cases)according to whether they recurred within 6 months after interventional therapy.The clinicopathologic characteristics of the two groups were compared;Logistic regression analysis was applied to identify the related factors affecting the prognosis and recurrence of patients with liver cancer after interventional therapy;ROC curve was drawn to evaluate the predictive value of FGF19 and GDF15 for the prognosis and recurrence of patients with liver cancer after interventional therapy.Results Expression levels of serum FGF19 and GDF15 decreased in liver cancer patients after interventional therapy(P＜0.05);Expression levels of FGF19 and GDF15 in serum of patients with recurrence were significantly higher than those of patients without recurrence(P＜0.05);The proportion of patients with low differentiation in the recurrent group was significantly higher than that in the non-recurrent group(P＜0.05);The degree of low differentiation,the increases of FGF19 and GDF15 were the risk factors of recurrence in patients with liver cancer after interventional therapy(P＜0.05);The area under the curve(AUC)for predicting prognosis recurrence in patients with liver cancer undergoing interventional therapy using serum FGF19,GDF15,or AFP detection alone were 0.734,0.791,and 0.883,respectively,while the AUC of combined detection of the two markers was 0.886,and the combined detection of the two markers was superior to the individual detection of serum FGF19 and GDF15(Z combination-GF19=2.294,Z combination-GF15=1.946,P=0.022,0.048).Conclusion The elevated expression of FGF19 and GDF15 in serum will promote the recurrence of patients with liver cancer after interventional therapy.The combined detection of FGF19 and GDF15 has a good predictive value for the prognosis of patients with liver cancer after interventional therapy.
NETL
NSTL
万方数据
维普
