摘要
目的 探究贫血与非贫血孕妇血红蛋白(Hb)、维生素A(VA)、铁蛋白(SF)、锌(Zn)及内因子抗体(IFA)表达差异,并分析各指标表达与孕妇贫血的相关性.方法 选取2022年8月至2023年4月我院收治的102例贫血孕妇为贫血组(Hb＜110g/L),另选取同期102例非贫血孕妇为非贫血组,检测两组Hb、VA、SF、Zn、IFA表达水平,分析孕妇贫血的影响因素,将贫血组根据外周血 Hb水平进行贫血程度划分[轻度(100g/L≤Hb＜110g/L)、中度(70g/L≤Hb＜99g/L)],比较不同贫血程度孕妇、不同孕期贫血孕妇Hb、VA、SF、Zn、IFA表达差异,分析Hb、VA、SF、Zn、IFA表达水平与贫血孕妇孕期、贫血程度的相关性,并分析Hb、VA、SF、Zn、IFA表达对中度贫血的预测价值.结果 两组孕周、妊娠期合并症相比,差异有统计学意义(P＜0.05);贫血组中度、轻度贫血孕妇Hb、VA、SF、Zn均低于非贫血组,IFA高于非贫血组(P＜0.05),中度贫血孕妇Hb、VA、SF、Zn表达水平低于轻度贫血孕妇,IFA表达水平高于轻度贫血孕妇(P＜0.05);不同孕期贫血孕妇Hb、VA、SF、Zn表达水平比较,孕晚期＜孕中期＜孕早期,IFA表达水平比较,孕早期＜孕中期＜孕晚期(P＜0.05);Hb、VA、SF、Zn与贫血孕妇孕期、贫血程度呈负相关,IFA与贫血孕妇孕期、贫血程度呈正相关(P＜0.05);孕周、妊娠期合并症、Hb、VA、SF、Zn、IFA是孕妇贫血的影响因素(P＜0.05);Hb、VA、SF、Zn、IFA联合预测中度贫血的AUC为0.933,大于各参数单独预测(P＜0.05).结论 贫血孕妇Hb、VA、SF、Zn、IFA表达明显异常,且Hb、VA、SF、Zn、IFA与贫血孕妇孕期、贫血程度联系密切,联合检测对预防孕妇中度贫血具有重要价值.
Abstract
Objective To explore differences in expressions of hemoglobin(Hb),vitamin A(VA),ferritin(SF),zinc(Zn)and internal factor antibody(IFA)between anemia and non-anemia pregnant women,and to analyze the correlation between the expression of each index and anemia in pregnant women.Methods 102 anemic pregnant women admitted to our hospital from August,2022 to April,2023 were selected as the anemic group(Hb＜110g/L),while another 102 non-anemic pregnant women were selected as the non-anemic group during the same period.Expression levels of Hb,VA,SF,Zn and IFA were measured in both groups,and the factors influencing the anemia of pregnant women were analyzed,and the anemic group was classified into anemia degrees according to the peripheral blood Hb concentration[mild(100g/≤Hb＜110g/L),moderate(70g/L≤Hb＜99g/L)].Differential expressions of Hb,VA,SF,Zn and IFA in pregnant women with different degrees of anemia were compared.The correlation between expression levels of Hb,VA,SF,Zn and IFA and the degree of anemia was analyzed.The predictive value of expressions of Hb,VA,SF,Zn and IFA in severe anemia was analyzed.Results We compared these two groups in terms of gestational weeks and gestational comorbidities and the differences were statistically significant(P＜0.05);Hb,VA,SF and Zn in moderately and mildly anemic pregnant women in the anemic group were lower than those in the non-anemic group,while IFA was higher than that in the non-anemic group(P＜0.05);Expression levels of Hb,VA,SF and Zn in moderately anemic pregnant women were lower than those in mildly anemic pregnant women,while the expression level of IFA were higher than those in mildly anemic pregnant women(P＜0.05);Expression levels of Hb,VA,SF and Zn in pregnant women with different degrees of anemia were compared and results were as follows:severe anemia＜moderate anemia＜mild anemia＜IFA,and mild anemia＜moderate anemia＜severe anemia(P＜0.05);Expression levels of Hb,VA,SF and Zn in pregnant women with different anemia during pregnancy were compared as follows:late trimester＜middle trimester＜early trimester;IFA was compared as follows:early trimester＜middle trimester＜late trimester(P＜0.05);Hb,VA,SF and Zn were negatively correlated with pregnancy and degree of anemia in pregnant women,while IFA was positively correlated with pregnancy and degree of anemia in pregnant women(P＜0.05).Gestational age,complications during pregnancy,annual family income,Hb,VA,SF,Zn and IFA were the factors affecting anemia in pregnant women(P＜0.05).AUC for the combination of Hb,VA,SF,Zn and IFA to predict moderate anaemia was 0.933,which was greater than the value of each marker alone(P＜0.05).Conclusion Expressions of Hb,VA,SF,Zn and IFA are significantly abnormal in anaemic pregnant women,and Hb,VA,SF,Zn and IFA are closely associated with the gestation period and degree of anaemia,suggesting the combined test is of great value in preventing moderate anaemia in pregnant women.
基金项目
北京京煤集团总医院院级科研基金项目(2021-13)
NETL
NSTL
维普
万方数据