慢阻肺急性加重期并发呼吸衰竭患者血清PTX3、MyD88水平及其预后价值
Levels and Prognostic Value of Serum PTX3 and MyD88 in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Respiratory Failure
夏菲 1张艳艳 1张云1
作者信息
- 1. 南京医科大学附属苏州医院重症医学科,江苏苏州 215008
- 折叠
摘要
目的 探讨慢阻肺急性加重期(AECOPD)并发呼吸衰竭患者血清正五聚蛋白 3(PTX3)、髓样分化因子88(MyD88)水平及其预后价值.方法 选取本院2020年1月至2021年12月期间收治的137例AECOPD并发呼吸衰竭患者作为研究组,另外选取137例单纯AECOPD未合并呼吸衰竭患者作为对照组,研究组根据1年内的预后状态,分为生存组110例和死亡组27例.Pearson法分析血清PTX3和MyD88表达水平的相关性,Logistic回归分析影响AECOPD并发呼吸衰竭的相关因素,受试者工作特征曲线分析血清PTX3和MyD88对AECOPD并发呼吸衰竭患者预后状态的预测效能.结果 研究组血清PTX3和MyD88表达水平均显著高于对照组(P＜0.05);AECOPD并发呼吸衰竭患者血清PTX3和MyD88表达水平呈正相关(r=0.741,P＜0.05);研究组与对照组心脏疾病及每年AECOPD发生次数差异存在统计学意义(P＜0.05);心脏疾病、每年AECOPD发生次数、PTX3及MyD88为AECOPD并发呼吸衰竭的影响因素(P＜0.05);死亡组患者血清PTX3和MyD88表达水平均高于生存组(P＜0.05);血清PTX3、MyD88以及二者联合预测AECOPD并发呼吸衰竭患者预后状态的曲线下面积分别为0.784、0.748、0.871,二者联合检测优于血清PTX3、MyD88各自单独检测(Z二者联合-PTX3=2.245、Z二者联合-MyD88=1.991,P=0.025、0.046).结论 血清PTX3、MyD88表达水平与AECOPD并发呼吸衰竭的发生密切相关,二者联合检测对AECOPD并发呼吸衰竭患者预后状态具有较高预测效能.
Abstract
Objective To investigate serum levels of pentraxin-3(PTX3)and myeloid differentiation factor 88(MyD88)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with respiratory failure and their prognostic values.Methods A total of 137 AECOPD patients with respiratory failure admitted to our hospital from January,2020 to December,2021 were regarded as the study group,while 137 simple AECOPD patients without respiratory failure were regarded as the control group.The study group was further grouped into a survival group of 110 cases and a death group of 27 cases based on the prognosis within one year.Pearson method was applied to evaluate the correlation between serum PTX3 and MyD88 expression levels,Logistic regression analysis was conducted to identify related factors affecting AECOPD complicated with respiratory failure.Receiver operating characteristic curve was drawn to analyze the predictive efficacy of serum PTX3 and MyD88 in predicting the prognosis of AECOPD patients with respiratory failure.Results Expression levels of serum PTX3 and MyD88 in the study group were significantly higher than those in the control group(P＜0.05);Expression levels of serum PTX3 and MyD88 in AECOPD patients with respiratory failure were positively correlated(r=0.741,P＜0.05);There was a significant difference in the incidence of heart disease and annual AECOPD between the research group and the control group(P＜0.05);Heart disease,annual incidence of AECOPD,PTX3 and MyD88 were the influencing factors for AECOPD complicated with respiratory failure(P＜0.05);Expression levels of serum PTX3 and MyD88 in the death group were higher than those in the survival group(P＜0.05);The area under the curve of serum PTX3,MyD88,and their combination in predicting the prognosis of AECOPD patients with respiratory failure were 0.784,0.748,and 0.871,respectively.The combined detection of two markers was superior to the individual detection of serum PTX3 or MyD88(Zcombincd-PTX3=2.245,Zcombined-myD88=1.991,P=0.025,0.046).Conclusion Expression levels of serum PTX3 and MyD88 are closely related to the occurrence of respiratory failure in AECOPD patients.The combined detection of these two markers has a high predictive power for the prognosis of AECOPD patients with respiratory failure.
关键词
慢阻肺急性加重期/呼吸衰竭/正五聚蛋白3/髓样分化因子88/预后Key words
Acute exacerbation of chronic obstructive pulmonary disease/Respiratory failure/Pentraxin-3/Myeloid differentiation factor 88/Prognosis引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据