首页|血脂对血糖控制不佳的2型糖尿病患者的预测价值研究

血脂对血糖控制不佳的2型糖尿病患者的预测价值研究

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  • NETL
  • NSTL
  • 万方数据
  • 维普
目的 探讨不同血糖控制水平的2型糖尿病(T2DM)患者血脂的差异,并研究血脂对血糖控制不佳的T2DM患者的预测价值.方法 收集核工业416医院2021年1月至2022年12月的89例T2DM患者的临床资料,按糖化血红蛋白水平分成两组,并对其进行回顾性分析.结果 血糖控制不佳组的胆固醇(CHO)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(ApoB)、ApoB/ApoA1和小而密低密度脂蛋白(sdLDL-C)明显高于血糖控制良好组(P＜0.05);经年龄、性别和BMI 调整后,HBA1c 与 CHO(r=0.318,P=0.003)、NEFA(r=0.296,P=0.003)、LDL-C(r=0.404,P=0.001)、ApoB(r=0.349,P=0.001)、ApoB/ApoA1(r=0.341,P=0.001)和 sdLDL-C(r=0.315,P=0.003)呈 明显正 相关.ApoB、LDL-C 及sdLDL-C可预测血糖控制不佳的T2DM患者(ApoB:灵敏度和特异性分别为65.1％和80.4％;LDL-C:灵敏度和特异性分别为 81.4％和 67.7％;sdLDL-C:灵敏度和特异性分别为 69.8％和 71.7％).结论 CHO、NEFA、LDL-C、ApoB、sdLDL-C 和ApoB/ApoA1水平与T2DM患者的糖化血红蛋白水平有明显相关性,ApoB、LDL-C及sdLDL-C对血糖控制不佳的T2DM患者具有良好的预测价值.
The Predictive Value of Lipids in Patients with Type 2 Diabetes Mellitus with Poor Glycemic Control
Objective The objective of this study is to examine variations in blood lipids among individuals diagnosed with type 2 diabetes mellitus(T2DM)who exhibit varying degrees of blood glucose control.Furthermore,this research aims to assess the potential predictive capacity of blood lipids in T2DM patients with inadequate blood glucose control.Methods The clinical data of 89 patients diagnosed with type 2 diabetes mellitus(T2DM)at China National Nuclear Corporation 416 Hospital between January,2021 and December,2022 were gathered and subsequently categorized into two groups based on their HBA1c levels.These datasets were then subjected to a retrospective analysis.Results Concentrations of cholesterol(CHO),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),apolipoprotein B(ApoB),ApoB/ApoA1,and small but dense low-density lipoprotein(sdLDL-C)were found to be significantly elevated in the poorly controlled blood glucose group compared to the well-controlled blood glucose group(P＜0.05).After adjusting for covariates including age,sex,and BMI,the results showed significant positive correlations between HBA1c and several biomarkers,including CHO(r=0.318,P=0.003),NEFA(r=0.296,P=0.003),LDL-C(r=0.404,P=0.001),ApoB(r=0.349,P=0.001),ApoB/ApoA1(r=0.341,P=0.001),and sdLDL-C(r=0.315,P=0.003).Furthermore,ApoB,LDL-C,and sdLDL-C were found to be predictive for poor glycemic control in patients with type 2 diabetes mellitus(ApoB:sensitivity of 65.1％and specificity of 80.4％;LDL-C:sensitivity of 81.4％and specificity of 67.7％;sdLDL-C:sensitivity of 69.8％and specificity of 71.7％).Conclusion Levels of CHO,NEFA,LDL-C,ApoB,sdLDL-C,and ApoB/ApoA1 exhibit a significant correlation with glycated hemoglobin levels in patients with type 2 diabetes mellitus(T2DM).Furthermore,ApoB,LDL-C,and sdLDL-C demonstrate a strong predictive capacity for T2DM patients who have inadequate glycemic control.

Lipid metabolismType 2 diabetesPoor glycemic controlPredictive value

陈霄、韦祎、曾志荣

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成都医学院第二附属医院核工业四一六医院检验科,四川成都 610057

血脂 2型糖尿病 血糖控制不佳 预测价值

成都市医学科研课题

2022266

2024

10.11748/bjmy.issn.1006-1703.2024.02.011

标记免疫分析与临床
中国同辐股份有限公司

标记免疫分析与临床

CSTPCD
影响因子：0.978
ISSN：1006-1703
年,卷(期)：2024.31(2)
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