摘要
目的 探讨脂蛋白相关磷脂酶A2(Lp-PLA2)与可溶性凝集素样氧化型低密度脂蛋白受体1(sLOX-1)对急性脑梗死的发生、复发及TOAST分型的关系.方法 选取2021年7月至2023年1月,我院收治的急性脑梗死患者181例,健康对照组154例.急性脑梗死患者根据病史被分为首发和复发;根据TOAST分型被分为大动脉粥样硬化型(LAA),小动脉闭塞型(SAO).比较各组间Lp-PLA2与sLOX-1的水平差异;采用Logistic回归分析急性脑梗死复发的危险因素.结果 疾病组的Lp-PLA2、sLOX-1水平显著高于健康对照组,差异有统计学意义;复发组Lp-PLA2、sLOX-1显著高于首发组,差异有统计学意义;sLOX-1水平在LAA组显著高于SAO(P=0.047),Lp-PLA2在两组间差异无统计学意义.结论 Lp-PLA2与sLOX-1与急性脑梗死相关,是急性脑梗死复发的危险因素.此外,sLOX-1与急性脑梗死的病因相关.
Abstract
Objective To investigate the relationship between lipoprotein-associated phospholipase A2(Lp-PLA2)and soluble lectin-like oxidized low density lipoprotein receptor 1(sLOX-1)on recurrence of acute cerebral infarction and TOAST classification.Methods 181 patients with acute cerebral infarction(ACI)admitted to our hospital from July,2021 to January.2023 and 154 healthy control groups were selected for the study.Patients with ACI were divided into the first onset and recurrence according to their medical history,and large atherosclerosis type(LAA)and small artery occlusion type(SAO)according to TOAST classification.Levels of Lp-PLA2 and sLOX-1 were compared among all groups.Logistic regression was performed to analyze the risk factors of recurrent acute cerebral infarction.Results Levels of Lp-PLA2 and sLOX-1 in ACI were significantly higher than those in the healthy control group;The Lp-PLA2 and sLOX-1 levels in the recurrent group were significantly higher than those in the first onset group;The level of sLOX-1 in the LAA group was significantly higher than that in SAO.There was no difference in Lp-PLA2 between the two groups.Conclusion Lp-PLA2 and sLOX-1 can serve as indicators for predicting acute cerebral infarction,and are risk factors for recurrence of acute cerebral infarction.sLOX-1 is also associated with the etiology of acute cerebral infarction.
基金项目
广西壮族自治区卫生健康委员会自筹经费课题(Z20211105)
NETL
NSTL
维普
万方数据