The Application of Combined Detection of PLA2,Hs-CRP and FIB in the Diagnosis of Acute Cerebral Infarction
Objective To explore the clinical values of combined detection of lipoprotein-associated phospholipase A2(Lp-PLA2),high-sensitivity C-reactive protein(hs-CRP)and plasma fibrinogen(FIB)in the diagnosis of acute cerebral infarction(ACI).Methods A total of 240 inpatient who were diagnosed with ACI were selected as the research objects(cerebral infarction group),while 100 healthy people were selected as the control group.The general clinical data and the detection indicators between these two groups were compared;NIHSS scores in the cerebral infarction group were assessed.The relationship between levels of plasma Lp-PLA2,hs-CRP and FIB and the degree of neurological deficit in patients with ACI was analyzed,and the risk factors of ACI were determined by multivariate logistic regression analysis.In addition,the diagnostic value of Lp-PLA2,hs-CRP and FIB for ACI was evaluated by calculating the areas under the ROC curves(AUC).Results Levels of Lp-PLA2,hs-CRP and FIB in patients plasma with severe cerebral infarction were higher than those in patients with mild and moderate cerebral infarction(P＜0.05).Compared with the control group,the plasma levels of Lp-PLA2,hs-CRP and FIB in patients with cerebral infarction were significantly higher(P＜0.05).Levels of Lp-PLA2,hs-CRP and FIB were significantly correlated with the risk of ACI(P＜0.05).Among the three indexes of Lp-PLA2,hs-CRP and FIB,Lp-PLA2 had the biggest area under the ROC curve and the highest diagnostic value.The combination of Lp-PLA2,hs-CRP and FIB could significantly improve the diagnostic efficiency of ACI.Conclusion There is a high clinical value of the combined detection of Lp-PLA2,hs-CRP and FIB in the diagnosis of the degree of neurological deficit in patients with ACI.
NETL
NSTL
万方数据
维普
