Clinical Values of Serum CEA,SCC,CYFRA21-1,NSE Combined with CT Scanning in the Diagnosis of Non-small Cell Lung Cancer
Objective To evaluate the application value of carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC),cytokeratin fragment 21-1(CYFRA21-1),neuron-specific enolase(NSE),and combined with CT scan in the diagnostic detection of non-small cell lung cancer.Methods A total of 58 patients with non-small cell lung cancer diagnosed in Nanjing Yuhua Hospital from January,2020 to December,2022 were enrolled as the observation group,including 30 cases of adenocarcinoma,10 cases of large cell carcinoma and 18 cases of squamous cell carcinoma.During the same period,58 healthy volunteers examined in outpatient clinics were included as a control group.The expression levels of CEA,SCC,CYFRA21-1 and NSE in serum samples were analyzed by chemiluminescence.CT scan was applied for the combined diagnosis.Results Serum levels of CEA,SCC,CYFRA21-1 and NSE in the observation group were significantly higher than those in the control group(P＜0.05).CEA expression levels were correlated with adenocarcinoma tumor size diagnosed by CT;Serum levels of CEA were related to tumor size in large cell carcinoma;SCC,CYFRA21-1 and NSE were associated with squamous cell carcinoma.Conclusion The use of serum SCC,CYFRA21-1,NSE and CEA combined with CT scan has a high sensitivity and diagnostic accuracy for the diagnosis of non-small cell lung cancer.It can provide a clinical diagnostic reference.
NETL
NSTL
万方数据
维普
