The Analysis of Distribution and Drug Resistance of Carbapenem-resistant Enterobacter Strains in an Infectious Disease Hospital From 2019 to 2023
Objective To analyze the strain distribution and drug resistance of Carbapenem-resistant enterobacter (CRE)in an infectious disease hospital from 2019 to 2023,in order to better guide clinical drug usage and to provide data-driven evidence for the control of multi-drug resistant bacteria in the hospital. Methods The clinical isolated CRE strains and patient information during 2019-2023 were collected,and the strain distribution and drug resistance characteristics were retrospectively analyzed.Results From 2019 to 2023,the detection rates of CRE in enterobacter were 16.44％,27.91％,41.11％,38.35％ and 42.55％, respectively,showing an overall upward trend.Among all CRE strains,the highest detection rates were CRKP,CREC and CRECL.From the perspective of specimen sources,sputum,ascites and blood accounted for the largest proportion of specimens.From the perspective of age distribution,the proportion of middle-aged and elderly people between 40 and 70 years old was relatively high,while the proportion of 0-60 years old was increasing,and the proportion of over 60 years old was decreasing.The resistance rates of the three strains to ertapenem were higher than that of imipenem and meropenem,while the resistance rates to polymyxin and tigacycline were lower,and the antimicrobial resistance spectrum was different.Conclusion The detection rate of CRE in infectious diseases hospitals is relatively higher,and there are differences in clinical distribution of specimen type and patient age.The drug resistance spectra of different strains are also different.Hospitals should continue to reinforce bacterial resistance monitoring and develop effective prevention and control measures to reduce the spread of drug-resistant bacteria.
万方数据
维普
