Objective To analyze the human papillomavirus (HPV)infection status in male patient population in Beijing area,and to provide data-driven support for its prevention and treatment strategies.Methods A retrospective analysis was conducted on the HPV infection status of clinical male patients from 2020 to 2022. Multichannel real-time fluorescence quantitative polymerase chain reaction (PCR)was applied for HPV DNA subtype detection,which included 15 high-risk HPV subtypes (HPV16,18,31,33,35,39,45,51, 52,56,58,59,66,68,82)and 2 low-risk HPV subtypes (HPV 6&11).The HPV infection events of male patients at different age groups and disease types were statistically analyzed.We also analyzed the individual and mixed infections among different HPV subtypes.Results From 2020 to 2022,a total of 7024 male patients'secretion samples were collected for HPV DNA subtype detection.The positive rate of HPV infection was 39.76％ (2793 cases).Among different disease types,skin infection and viral warts were the main diseases.The 21-30 age group was the highest proportion of HPV infection with 1143 cases (16.27％),followed by 31-40 aged group with 1109 cases (15.79％).Compared with other age groups,there was a statistically significant difference (x2=27.342,P<0.001 ).Among different HPV subtypes infection,the single subtype infection was the highest with 1744 cases (24.83％)(x2=20.431,P<0.001),followed by double subtype infection (619 cases,8.81％)and triple infection (249 cases,3.54％).Among single HPV subtypes infection,HPV 6&11 subtype (low risk type)was the highest (445 cases,6.34％),followed by 16 subtype (229 cases,3.26％)and 52 subtype (211 cases, 3.00％);Among the multiple infections of HPV subtypes,HPV 6&11/16 were the highest in secondary infections (135 cases,1.92％),while HPV 6&11/16/52 were the highest in triple infections (29 cases,0.41％), and HPV6&11/51/52/58 were the highest in quadruple infections (10 cases,0.14％).Conclusion During the period of 2020 to 2022,the high incidence of HPV infection in male population was between the ages of 21 and 40.The main HPV subtypes infected were 6&11,16,52,58,and 51. Single subtype was the main type infection.This study provides a reliable data-driven support for the prevention and treatment of male HPV infection in this region.
维普
万方数据