A Study on the Value of HCV Serological Antibody and High-sensitivity HCV RNA for Screening and Detection of Viral Hepatitis C
Objective Toretrospectively assess the outcomes of HCV serological antibody and high-sensitivity HCV RNA testing on inpatients requiring surgery,blood transfusion,or other invasive medical services at our hospital from January,2019 to September,2022 in order to assess their values.To further study the value of hepatitis C antibody detection and HCV highly sensitive nucleic acid detection in screening and detection of viral hepatitis C.Methods Elecsys Anti-HCV Ⅱ or/and high-sensitivity HCV RNA detection was performed on relevant inpatients in our hospital,and the detection results were statistically analyzed.Results 2443 people were tested for HCV serological antibody,the positive rate was 0.68％,and the median positive COI was 38.4 (1.00-165).High-sensitivity HCV RNA was detected for 34,628 people,with a positive rate of 0.30％.The median positive viral load was 1.00×106IU/mL (3.50×101-4.00× 107 IU/mL).The 45-59-year-old population exhibited a significantly higher positive rate than other populations,as demonstrated by both methodologies (P<0.001 ).A total of 17,785 samples were overlapped by the two tests,and the HCV antibody serological positive rate was 0.70％.The positive rate of high-sensitivity HCV RNA was 0.22％.If high-sensitivity HCV RNA was used as the standard for current hepatitis C infection,the sensitivity of HCV antibody serology to detect HCV current infection was 100.00％ (95％ CI 89.09％-100.00％),specificity,the degree of accuracy was 99.52％(95％ CI 99.41％-99.61％),the positive predictive period PPV of current infection was 32.00％(95％ CI 23.82％-40.18％),and the negative predictive value was 100.00％.No linear relationship exists between the COI of HCV antibody serological detection and the viral load of high-sensitivity HCV RNA detection,and the rate of HCV RNA being positive when COI was less than 10 and higher than 100 was low.Conclusion HCV antibody detection and high-sensitivity HCV RNA are both effective screening methods for hepatitis C,and it is necessary to further strengthen the management of hepatitis C infection in key populations.
Hepatitis C virusAnti-HCVHCV RNAChemiluminescenceNucleic acid testing
万方数据
维普
