Objective To evaluate impacts of levocarnitine combined with nicorandil on vascular endothelial function and transient receptor potential channel 1 (TRPC1 )and N-terminal precursor brain natriuretic peptide (NT-proBNP)levels in patients with heart failure.Methods 150 patients with heart failure were randomly divided into 2 groups:the control group was treated with nicodil,while the study group was treated with levocarnitine combined with nicodil.All patients were treated for 3 months.The curative effect was evaluated after treatment,and the vascular endothelial function and TRPC1 ,NT-proBNP levels were compared between groups.Results The total effective rate of the study group was higher than that of the control group (P<0.05);After treatment,levels of serum endothelin-1 (ET-1),TRPC-1 and N-terminal pro-brain natriuretic peptide (NT-proBNP)in the study group were lower than those in the control group (P<0.05);Nitric oxide (NO)and brachial artery flow-mediated diameter (FMD)were higher than those in the control group (P<0.05).Conclusion Compared with nicoradil alone,the combination of L-carnitine in the treatment of heart failure patients can improve the efficacy,regulate the levels of serum TRPC-1 and NT-proBNP,reduce the severity of patients'disease,and improve vascular endothelial function.
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