The Value of Serum CD62P and sTREM-1 Levels in Predicting the Occurrence of Major Cardiovascular Adverse Events in Elderly Patients with Coronary Heart Disease After PCI
Objective To explore the predictive value of serum P-selectin (CD62P)and soluble myeloid cell expression triggering factor receptor 1 (sTREM-1 )levels for major cardiovascular adverse events in elderly patients with coronary heart disease after percutaneous coronary intervention (PCI).Methods A total of 160 elderly patients diagnosed with coronary heart disease who were treated in our hospital from January,2019 to January,2022 were selected as the study subjects.The level of CD62P in serum sample was detected by flow cytometry;Human sTREM-1 ELISA kit was applied to detect the level of sTREM-1 in serum samples;According to the follow-up results during 12 months after discharge,the elderly patients with coronary heart disease were divided into two groups:the non-cardiovascular adverse events group (108 cases)and the cardiovascular adverse events group (52 cases);Multivariate logistic regression was applied to analyze the risk factors of major cardiovascular adverse events in elderly patients with coronary heart disease after PCI;ROC curve was drawn to evaluate the predictive value of serum levels of CD62P and sTREM-1 for the occurrence of major adverse cardiovascular events in elderly patients with coronary heart disease after PCI. Results Compared with the non-cardiovascular adverse events group,serum levels of CD62P and sTREM-1 in the cardiovascular adverse events group were higher (P<0.05);The medical history of diabetes,angina pectoris,the number of coronary artery lesions,and the number of stents were related to the occurrence of cardiovascular adverse events (P<0.05 );Multivariate logistic regression analysis showed that high expression of CD62P,high expression of sTREM-1,medical history of diabetes,angina pectoris,number of coronary artery lesions >1,and number of stents >2 were risk factors (P<0.05);AUC of CD62P and sTREM-1 in predicting major adverse cardiovascular events was significantly higher than that of CD62P alone (Z=3.116,P=0.002).Conclusion Levels of serum CD62P and sTREM-1 have certain predictive value for the occurrence of major adverse cardiovascular events in elderly patients with coronary heart disease after PCI.
万方数据
维普
