Changes of ACR,PLT and D-D in Patients with PE and Their Predictive Values for Adverse Pregnancy Outcomes
Objective To investigate changes of albuminuria to creatinine ratio (ACR),platelet count (PLT) and D-dimer (D-D)in patients with preeclampsia (PE)and their predictive values for adverse pregnancy outcomes.Methods A total of 103 patients with PE treated in the hospital were retrospectively enrolled as PE group between October,2019 and October,2022,while 40 normal pregnant women during the same period were enrolled as the control group.Levels of ACR,PLT and D-D in these two groups were detected. According to the disease severity,PE patients were divided into the severe group and mild group,and levels of ACR,PLT and D-D in these two groups were compared.According to different pregnancy outcomes,PE patients were divided into the good outcome group and poor outcome group,and levels of ACR,PLT and D-D in these two groups were compared.The evaluation value of ACR, PLT and D-D for adverse pregnancy outcomes was analyzed.Results Levels of ACR and D-D in PE group were higher than those in the control group,while PLT was lower (P<0.05).Levels of ACR and D-D in the severe group were higher than those in the mild group,while PLT was lower than that in the mild group (P<0.05).Levels of ACR and D-D in the poor outcome group were higher than those in the good outcome group,while PLT was lower (P<0.05).ROC curves analysis showed that AUC and cut-off values of ACR,PLT and D-D for evaluating adverse pregnancy outcomes were (0.799,89.61 mg/mmol),(0.860,52.05 ×109/L)and (0.762, 1.52μg/mL),respectively.AUC of combined detection was 0.930,greater than that of single-index test (P<0.05).Conclusion Levels of ACR and D-D increase and PLT decreases in PE patients.These three indexes are related to disease severity,and the combined detection has a high evaluation value for adverse pregnancy outcomes.
PreeclampsiaAlbuminuria to creatinine ratioPlatelet countD-dimerAdverse pregnancy outcome
万方数据
维普
