The Research Progress of Baicalin in Pulmonary Hypertension
Pulmonary hypertension is a disease characterized by sustained increase of pulmonary vascular resistance, also pulmonary vascular obstruction, vascular remodeling, right ventricular hypertrophy,and function failures.The pathogenesis of pulmonary arterial hypertension includes pulmonary endothelial cell dysfunction and pulmonary smooth muscle cell proliferation.New drugs and treatment options are urgently needed in clinical practices.Studies have shown that baicalin is effective in the treatment of pulmonary hypertension,but mechanisms remain unclear.This article reviewed the pharmacokinetics of baicalin and the potential therapeutic mechanisms of baicalin for pulmonary hypertension,including anti-inflammatory response,stabilization of extracellular matrix, reduction of oxidative stress, inhibition of lung smooth muscle cell proliferation, endothelium-interstitial transformation,providing a knowledge basis for traditional Chinese medicine treatment of pulmonary arterial hypertension.
万方数据
维普
