An Analysis of Antimicrobial Resistance and Distribution of Pathogenic Bacteria of Osteoarticular Infection in Patients with Different Ages
Objective The aim of this study was to analyze the distribution characteristics of pathogens and antibiotic resistance of osteoarticular infections (OAIs)in patients with different ages,and to provide relevant references for the clinical treatment of OAIs.Methods All positive bacterial culture cases of OAIs treated in our institution between 2016 and 2022 were analyzed,retrospectively.These patients were divided into the pediatrics group (≤16 years old),adults group (17-60 years old)and elderly group (≥60 years old).The antimicrobial susceptibility of clinical isolates was carried out by automated systems.The results were interpreted according to the Clinical and Laboratory Standards Institute Breakpoints (2022 Edition).Results A total of 1010 strains of pathogenic bacteria were isolated.The top 5 prevalent organisms were Staphylococcus aureus (31.1％),Staphylococcus epidermidis (12.2％),Escherichia coli (9.5％),Enterobacter cloacae (6.8％)and Pseudomonas aeruginosa (5.8％).Staphylococcus aureus was the first isolated bacteria in both children and adult patients,and Escherichia coli was the first isolated bacteria in the elderly patients.The MRSA detection rate of the elderly was 56.7％,while the MRSE detection rate of the adults was 81.8％.No vancomycin and linezolid resistant isolate were found.The resistance rates of P.aeruginosa to carbapenems,cefepime and ceftazidime were lower than 15.0％.E.cloacae in adults and E.coli in the elderly were demonstrated to be highly resistance to ceftriaxone (43.9％and 54.5％,respectively).No Enterobacter species resistant to carbapenems was detected.Conclusion The distribution of antimicrobial resistance profiles are different among age groups.Therefore,the appropriate antibiotics should be selected for clinical treatment according to patients'age and the results of antimicrobial sensitivity test.
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