Objective To investigate the prognostic value of the expressions of NPM1 and PRDX6 in preoperative serum for colon cancer after radical resection.Methods 162 patients who underwent radical colon cancer surgery at Zhabei Central Hospital in Jing'an District,Shanghai from September 2017 to October 2018 were selected as the colon cancer group,while 100 healthy physical examinees in our hospital during the same period were selected as the healthy group.The expression levels of NPM1 and PRDX6 mRNA were detected by qRT-PCR.Person correlation analysis was applied to analyze the correlation between NPM1 and PRDX6 expressions in serum,and Kaplan Meier survival curve was drawn.Log rank test was used to compare the survival time of those with high and low expressions of NPM1 and PRDX6.Results The relative expressions of NPM1 and PRDX6 mRNA in serum of patients with colon cancer were significantly higher than those of healthy controls (P<0.05);There were significant differences in the levels of NPM1 and PRDX6 mRNA in the serum of colon cancer patients with different TNM stages,lymph node metastasis,differentiation and tumor invasion depth (P<0.05);NPM1 and PRDX6 were positively correlated (r=0.534,P<0.001);The survival rate of patients with high expression of NPM1 was significantly lower than that of patients with low expression of NPM1 (P<0.05);Cox multivariate analysis showed that TNM stage,lymph node metastasis,degree of differentiation,NPM1 and PRDX6 were the risk factors affecting the prognosis of patients with colon cancer (P<0.05).Conclusion NPM1 and PRDX6 are highly expressed in the serum of patients with colon cancer.The expressions of NPM1 and PRDX6 are related to TNM stage,lymph node metastasis,degree of differentiation,depth of tumor invasion and prognosis,and could serve as a molecular marker to facilitate the prognosis of colon cancer.
维普
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