The Diagnostic Value of Dual Source CTA Combined with Serum Hcy and CysC for Intracranial Aneurysms
Objective To explore the diagnostic value of dual source CT angiography (CTA )combined with serum homocysteine (Hcy)and cystatin C (CysC)for intracranial aneurysm (IA).Methods From May,2021 to May,2023,125 suspected IA patients admitted to our hospital were collected as the study subjects.78 IA patients confirmed by digital subtraction angiography (DSA)diagnosis were selected as the case group,while the remaining 47 patients were as the control group.Serum Hcy and CysC levels of the two groups were compared.Receiver operating characteristic curve (ROC)was drawn to evaluate the diagnostic value of dual source CTA combined with serum Hcy and CysC levels for IA.Logistic model was applied to identify the factors that affected the occurrence of IA in patients.Results The case group detected 61 IA patients through dual source CTA,with a sensitivity of 78.21％ and a specificity of 80.85％.Serum Hcy and CysC levels in the case group were higher than those in the control group (P<0.05).The proportions of patients with hypertension and hyperlipidemia in the case group were higher than those in the control group (P<0.05).ROC analysis showed that the area under the curve (AUC)of serum Hcy and CysC were 0.807 (95％ CI 0.730-0.884)and 0.787 (95％ CI 0.705-0.869) for assisting in the diagnosis of IA,respectively.AUC of dual source CTA diagnosis of IA was 0.795 (95％ CI 0.711-0.879),and AUC of the combined diagnosis of the three markers was 0.933 (95％ CI 0.891-0.974),both of which were superior to their individual detection (Z=2.845,3.109,2.884,P<0.05).Multivariate analysis showed that serum Hcy and CysC were risk factors affecting the occurrence of IA in patients (P<0.05).Conclusion The combination of dual source CTA and serum Hcy and CysC has certain clinical auxiliary diagnostic value for IA.
Intracranial aneurysmDual source CT angiographyHomocysteineCystatin CDiagnostic value
万方数据
维普
