A Correlation Analysis of Sex Hormones of Reproductive Age Women with Elevated Testosterone Levels
Objective To explore the differences in testosterone (T),progesterone (P),luteinizing hormone (LH),follicle stimulating hormone (FSH),estradiol (E2 ),and prolactin (PRL)detection results between high testosterone women of reproductive age and normal women populations,and to further evaluate the relationship between testosterone and sex hormones,so as to search for clinical reference indicators to assist in diagnosing hypertestosterolemia and determining elevated testosterone levels.Methods A total of 106 women of reproductive age who visited our Gynecology clinic site from May,2019 to January,2022 were enrolled as the high testosterone group,while 60 women of normal menstrual cycle and follicular period who underwent pre-pregnancy physical examinations were selected as the control group.The differences in sex hormone test results and the correlation between testosterone and sex hormones between the two groups were then analyzed.Results In the normal control group,sex hormone levels were T 30.00 (20.00,43.30)ng/mL,P 0.29 (0.22,0.39)ng/mL,LH 5.06 (3.48,8.31)mIU/mL,FSH 5.81 (4.82,7.13)mIU/mL,E248.95 (35.14,88.00)pg/mL,and PRL10.20(7.55,18.20)ng/mL;High testosterone group were T 86.10 (76.25,140.00)ng/mL,P 0.50 (0.38,0.55)ng/mL,LH 7.05(4.57,9.65)mIU/mL,FSH 5.81(4.69,6.40)mIU/mL,E245.64(32.30,64.81)pg/mL,and PRL10.00(6.79,13.90)ng/mL;LH/FSH ratio in the normal control group was 0.91(0.56,1.41),while in the testosterone elevated group,LH/FSH ratio was 1.46 (1.07,1.84).LH/FSH and P levels in the testosterone elevated group were significantly higher than those in the control group (all P<0.05),while E2 level was significantly lower than that in the normal control group (P=0.029);There was no statistically significant difference in FSH,LH,and PRL levels between the two groups (all P>0.05).The T level in the normal control group was significantly positively correlated with LH,LH/FSH,and E2 (all P<0.05 or 0.01 ),but not significantly correlated with FSH,PRL,and P (P>0.05);The T level in the high testosterone group was only significantly negatively correlated with P (P<0.05),but had no significant correlation with other hormones (P>0.05).AUC for LH/FSH ratio assisting in the diagnosis for high testosterone was 0.73 (95％ CI 0.64-0.82 ),with a cutoff value of 1.30.Conclusion Patients with elevated testosterone have an elevated LH/FSH ratio,which is greater than 1.30 and has certain clinical reference values to assist in diagnosing hypertestosterolemia and determining elevated testosterone levels.The correlation between testosterone levels and sex hormones is inconsistent between normal and high testosterone women populations,indicating that hormone metabolism is disrupted in patients with elevated testosterone.Therefore,active testing of androgen related indicators should be carried out in clinical practice.
TestosteroneAndrogenReproductive age womanLH/FSH ratio
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