A Correlation Analysis Between Serum MMP12,CX3CR1 Levels and Severity of Obese Bronchial Asthma in Children
Objective To explore the correlation between serum matrix metalloproteinase 12 (MMP12),chemokine (C-X3-C motif)receptor 1 (CX3CR1)and the severity of obesity (OB)in children with bronchial asthma.Methods Two hundred children with bronchial asthma admitted to our hospital from September,2020 to May,2023 were collected as the research subjects.According to the diagnostic criteria for OB,these subjects were grouped into an OB group (100 cases)and a non-OB group (100 cases),and serum levels of MMP12 and CX3CR1 were compared between the two groups.Serum levels of MMP12 and CX3CR1 were compared among children with different lung function scores and disease severities.Pearson method was applied to analyze the relationship between serum MMP12 and CX3CR1 levels,lung function grading,and disease severity.Results Serum levels of MMP12 and CX3CR1 in the OB group were significantly increased (P<0.05).There was a statistically significant difference in serum MMP12 and CX3CR1 levels among children with different lung function score (P<0.05).As the pulmonary function grading worsened,serum levels of MMP12 and CX3CR1 in the children gradually increased (P<0.05).The difference in serum MMP12 and CX3CR1 levels among children with different disease severity levels was statistically significant (P<0.05).As the severity of the disease increased,serum levels of MMP12 and CX3CR1 in the children increased sequentially (P < 0.05 ).Correlation analysis showed that serum MMP12 level was positively correlated with lung function grading and disease severity (r=0.502,0.517,P<0.05),while serum CX3CR1 was positively correlated with lung function grading and disease severity (r=0.496,0.511,P<0.05).Conclusion Levels of serum MMP12 and CX3CR1 in children with OB bronchial asthma are significantly elevated,and are closely related to the disease severity and lung function.
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