The Correlation Analysis Between Expressions of Serum FGF2 and VEGF in Late Pregnancy Hypertensive Disorders of Pregnancy Patients and Fetal Growth Restriction
Objective To investigate the relationship between expressions of serum fibroblast growth factor 2 (FGF2),vascular endothelial growth factor (VEGF)and fetal growth restriction (FGR)in patients with hypertensive disorders of pregnancy (HDP).Methods Clinical data of 60 late pregnancy HDP complicated with FGR pregnant women (FGR group)and 60 HDP pregnant women without FGR (HDP group)who delivered in our hospital from January,2022 to December,2022 were collected for the study,while 60 healthy pregnant women during the same period were enrolled the control group.Serum FGF2 and VEGF levels were determined by enzyme linked immunosorbent assay (ELISA);Levels of serum FGF2 and VEGF were compared among pregnant women from the HDP group,FGR group,and control group;The influencing factors of FGR were identified by logistic regression;The relationship between serum FGF2,VEGF levels and neonatal body mass was analyzed by Pearson correlation method;The predictive value of serum of serum FGF2 and VEGF expression on FGR was investigated by receiver operating characteristic curve (ROC).Results There was no statistically significant difference in age,gestational age,BMI,and delivery method among the three groups (P>0.05),but there was a statistically significant difference in systolic blood pressure,diastolic blood pressure,and neonatal body mass (P<0.05);Compared with the control group,the serum FGF2 level increased (P<0.05)while VEGF level decreased (P<0.05)in the HDP and FGR groups,and the serum FGF2 level was higher (P<0.05)and VEGF level was lower in the FGR group than that in the HDP group;Logistic regression analysis indicated that systolic blood pressure,diastolic blood pressure,serum FGF2,VEGF levels were all independent influencing factors for FGR in late pregnancy HDP pregnant women (P<0.05);Receiver operating characteristic curve showed that the AUC of FGF2 and VEGF for predicting FGR in HDP pregnant women in the late pregnancy were 0.850 and 0.849,respectively,with the sensitivity of 76.7％,86.7％,and the specificity of 60.0％ and 60.0％,respectively;AUC of FGF2 and VEGF for diagnosing FGR in HDP pregnant women in the late pregnancy was 0.933,with the sensitivity of 88.3％,and the specificity of 76.6％.Conclusion Serum FGF2 level increases and VEGF level decreases in late pregnancy HDP pregnant women with FGR.Both can serve as risk factors for FGR in late pregnancy HDP pregnant women and have certain predictive value for FGR.
万方数据
维普
