The Impact of Dynamic Monitoring of Changes in Folic Acid,Vitamin B12 and Homocysteine During Pregnancy on Pregnancy Outcomes
Objective To explore the clinical significance of dynamically monitoring maternal serum folate (FA),vitamin B12 (VitB12 )and homocysteine (Hcy)levels during pregnancy in predicting pregnancy outcomes.Methods A prospective study was conducted on 200 pregnant women who underwent full pregnancy prenatal examination and delivery at our hospital from February,2020 to March,2022.Demographic data were recorded and serum FA,VitB12 and Hcy levels were measured in early,mid,and late pregnancy,respectively.Follow-up was conducted until delivery and we recorded pregnancy outcomes,and then divided them into a control group (102 cases with no adverse pregnancy outcomes)and an observation group (98 cases with adverse pregnancy outcomes)based on the presence or absence of adverse pregnancy outcomes.We compared levels of FA,VitB12 and Hcy between two groups of pregnant women at different stages.Results Serum levels of FA and VitB12 in the control group showed a significant downward trend with pregnancy time.Hcy level in mid pregnancy was significantly lower than that in early pregnancy.Although Hcy level in late pregnancy was significantly higher than that in mid pregnancy,it was significantly lower than that in early pregnancy (P<0.05).There was no significant difference in serum FA and VitB12 levels between the observation group in mid and late pregnancy (P>0.05),but they were significantly lower than those in early pregnancy (P<0.05).Hcy levels showed a significant downward trend with pregnancy time (P<0.05).Serum FA and ViB12 levels in the early and mid-pregnancy of the observation group were significantly lower than those in the control group,and Hcy levels were significantly higher than those in the control group (P<0.05).There was no statistically significant difference in levels of serum FA,VitB12 and Hcy,as well as the proportion of FA deficiency,VitB deficiency,and high Hcy in the late pregnancy between the two groups (P>0.05).FA deficiency,VitB deficiency,and high Hcy in early and mid-pregnancy were able to significantly increase the risk of adverse pregnancy (P<0.05).Conclusion FA deficiency,VitB12 deficiency,and high Hcy in early and mid-pregnancy can all increase the risk of adverse pregnancy outcomes.
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