18F-FDG PET/CT Metabolic Features Combined with HRCT Imaging Features in Differentiating Peripheral Lung Cancer from Inflammatory Lesions
Objective To assess the value of 18 F-FDG PET/CT metabolic features combined with HRCT imaging features in differentiating peripheral lung cancer (PLC)from inflammatory lesions.Methods A retrospective analysis was performed for 18 F-FDG PET/CT examination and pathologically confirmed or diagnosed with clinical follow-up in 91 cases of lung mass lesions from March,2015 to May,2023,including 61 cases in the PLC group and 30 cases in the inflammatory lesion group.HRCT imaging characteristics and 18 F-FDG metabolic characteristics of the two groups were analyzed with both univariate and multivariate analyses,and the differences in the characteristics between the two groups were then evaluated.The diagnostic performance of HRCT imaging feature method,18 F-FDG metabolic feature method and combined diagnosis was evaluated by calculating the area under the ROC curve (AUC),and the difference in diagnostic performance between the three was identified by Delong test.Results Univariate analysis showed that there were significant differences in diameter,air bronchitis,satellite sign,complete uptake and SUVmax between the two groups (P<0.05),while there were no significant differences in other HRCT imaging features and 18 F-FDG metabolic distribution (P>0.05).Multivariate analysis showed that diameter,air bronchial signs,satellite signs and SUVmax were valuable in differentiating peripheral lung cancer from inflammatory lesions (P<0.05),while complete uptake was not statistically significant (P>0.05).ROC curve showed that the AUC of joint diagnosis was the largest,and the results of Delong test showed that its diagnostic performance was better than HRCT imaging characteristic method and 18 F-FDG metabolic characteristic method (P<0.05),respectively.Conclusion 18 F-FDG PET/CT metabolic features combined with HRCT imaging features have a high clinical value in differentiating peripheral lung cancer from inflammatory lesions.
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