Parathyroid carcinoma (PC)is an extremely rare endocrine tumor.Compared with benign primary hyperparathyroidism (PHPT),PC is usually accompanied with severe and refractory hypercalcemia,and more likely to induce hypercalcemic crisis.The prognosis and overall survival rate of PC depend on the size of the primary tumor,tumor stage,invasion status at the time of the diagnosis,and the possibility of early surgical removal of all cancerous tissue,so accurate preoperative imaging evaluation is essential for PC treatment.This paper reports a case of 99 Tc m-MIBI negative PC patient diagnosed by multimodal imaging.This case study shows that multimodal imaging can complement each other in PC qualitative,positioning,quantitative and staging,which can be conducive to the preoperative diagnosis and prognosis evaluation of PC,as well as clinical decision-making process.
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