IL-6、PCT、CRP对老年人细菌性血流感染的诊断价值研究
A Study on the Diagnostic Value of IL-6,PCT and CRP in Bloodstream Infections
李孟涵 1蔡力力 1李玉茹 1曹荟哲 1朱红 1周玉1
作者信息
- 1. 中国人民解放军总医院第二医学中心检验科,国家老年疾病临床研究中心,北京 100853
- 折叠
摘要
目的 通过分析白介素6(IL-6)、降钙素原(PCT)、C-反应蛋白(CRP)水平,探讨3者在老年人细菌性血流感染(BSI)中的诊断价值.方法 选取2022年11月至2023年11月本院收治的204例60岁及以上患者为研究对象,其中116例血培养阳性患者为BSI组,88例血培养阴性患者为对照组,另根据血培养结果将BSI组分为革兰阳性菌(G+菌)感染组和革兰阴性菌(G-菌)感染组.采用SPSS 25.0软件比较BSI组与对照组、G+菌感染组与G-菌感染组之间IL-6、PCT和CRP水平;采用受试者工作特征曲线(ROC)评价3者单独或联合检测对BSI的诊断效能.结果 BSI组IL-6、PCT、CRP水平均高于对照组(P＜0.001);G-菌感染组IL-6、PCT水平明显高于G+菌组(P＜0.05);单项检测ROC曲线下面积PCT＞IL-6＞CRP,3者联合检测ROC曲线下面积高于单项检测,且特异性明显优于单项检测,为97.1％,灵敏度为62.1％.结论 IL-6、PCT、CRP 3者联合检测对老年人细菌性血流感染有较高的诊断价值,IL-6、PCT可有效鉴别G+菌与G-菌感染.
Abstract
Objective To evaluate the diagnostic value of interleukin-6(IL-6),procalcitonin(PCT)and C-reactive protein(CRP)in elderly patients with bacterial bloodstream infection(BSI).Methods 204 patients aged 60 years and above admitted to our hospital from November,2022 to November,2023 were selected as the study objects,of whom 116 patients with positive blood cultures were included in the BSI group,while 88 patients with negative blood cultures were in the control group.According to the results of blood culture,the BSI group was further divided into the Gram-positive bacteria(G+bacteria)infection group and Gram-negative bacteria(G-bacteria)infection group.Levels of IL-6,PCT and CRP were compared between the BSI group and control group,G+bacterial infection group and G-bacterial infection group by using SPSS 25.0 software.Receiver operating characteristic curve(ROC)was drawn to evaluate the diagnostic efficacy of these three tests with BSI alone or in combination.Results Levels of IL-6,PCT and CRP in the BSI group were higher than those in the control group(P＜0.001).Levels of IL-6 and PCT in G-bacterial infection group were significantly higher than those in G+bacteria group(P＜0.05).AUCs of the single detection showed a trend of PCT＞IL-6＞CRP,and AUC of the combined detection of the three markers was higher than that of the single-marker detection,and the specificity was significantly better than that of the single-marker detection,which was 97.1％and the sensitivity was 62.1％.Conclusion The combined detection of IL-6,PCT and CRP has a high diagnostic value for bacterial bloodstream infection in the elderly.IL-6 and PCT can effectively distinguish G+bacterial infection from G-bacterial infection.
关键词
血流感染/老年人/C-反应蛋白/降钙素原/白介素6Key words
Bloodstream infection/The elderly/C-reactive protein/Procalcitonin/Interleukin-6引用本文复制引用
基金项目
北京市自然科学基金资助项目(L234051)
出版年
2024
NETL
NSTL
万方数据