A Correlation Analysis Between Serum Estradiol Levels and Severity of Adenomyosis in Patients
Objective To explore the correlation between serum estradiol levels and the severity of uterine adenomyosis in patients.Methods 50 patients with adenomyosis who underwent hysterectomy in the Department of Gynecology of Jinan Fifth People's Hospital from June,2021 to October,2023 were selected as the observation group,while 50 healthy women during the same period were selected as the control group.According to the pathological results,adenomyosis of uterus was divided into mild,limited and severe types.Serum estradiol levels were detected by chemiluminescence immunoassay.COX dysmenorrhea Symptom Scale(CMSS)was used to assess the degree of dysmenorrhea in both groups:the higher the score,the more severe the dysmenorrhea.The anterior and posterior diameter,long diameter and transverse diameter of uterus were measured by vaginal ultrasonography before operation,and the volume of uterus was calculated.Results Compared with the control group,the serum estradiol level,CMSS score,and uterine volume of the study subjects in the observation group increased significantly(P＜0.05);There was a positive correlation between serum estradiol levels,CMSS scores,and uterine volume in both groups(r=0.345,P＜0.001,r=0.302,P=0.002);Compared with mild adenomyosis,subjects with localized adenomyosis had elevated serum estradiol levels(P＜0.05),while compared with localized adenomyosis,subjects with severe adenomyosis had elevated serum estradiol levels(P＜0.05);ROC curve showed that the sensitivity,specificity and AUC of mild and limited types of uterine adenomyosis were not different,and the diagnosis performance of severe types was the best.Conclusion The serum estradiol level in patients with adenomyosis is positively correlated with the severity of the condition.The higher the serum estradiol level,the more severe the condition of adenomyosis.Targeting serum estradiol levels has an important guiding significance for the early diagnosis and treatment of adenomyosis.
Adenomyosis of the uterusSerum estradiolDysmenorrheaUterine volumeThe severity of the conditionRelativity
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