Impacts of Huotan Tongluo Decoction Combined with Azithromycin on Tidal Volume and Serum Cytokine-like Protein 1 Level in Children with Mycoplasma Pneumonia
Objective To explore the therapeutic effect of Huotan Tongluo decoction combined with azithromycin on pediatric patients with mycoplasma pneumonia(MP),and to evaluate its impacts on lung function indicators,serum inflammatory factors,serum sPD-1 and CYTL1 levels.Methods Children with MP who were treated in our hospital from September,2022 to September,2023 were divided into an observer group(40 cases)and a control group(40 cases)by random number table method.The control group was treated with azithromycin based on routine treatment,while the observer group was treated with Huotan Tongluo decoction in addition to the control group.The treatment efficacy,lung function indicators,serum inflammatory factors,serum sPD-1 and CYTL1,and adverse reactions of all patients were compared and analyzed.Results The observer group had a better efficacy than the control group(P＜0.05);The lung function indicators VT,PEV1,and FVC were significantly increased,and the magnitude of elevation in the observer group was larger than that in the control group(P＜0.05);After treatment,serum IL-6,hs-CRP,and IL-8 levels were significantly decreased,and the magnitude of elevation in the observer group was higher than that in the control group(P＜0.05);After treatment,the expression level of serum sPD-1 decreased and the level of serum CYTL1 increased,and the amplitudes of the observer group were significantly higher than the control group(P＜0.05);During the treatment period of pediatric MP patients,the adverse reaction rate of the observer group was significantly lower than the control group(P＜0.05).Conclusion The combination of Huotan Tongluo decoction and azithromycin has a significant therapeutic effect on pediatric patients with MP,which can effectively improve lung function and regulate levels of inflammatory factors,serum sPD-1,and CYTL1.
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