体液免疫与成人斯蒂尔病患者住院次数相关分析
An Analysis of the Correlation Between Humoral Immunity and Hospitalization Times in Adults with Still's Disease
贾德天 1王慧娟2
作者信息
- 1. 北京市仁和医院呼吸内科,北京 102600
- 2. 首都医科大学附属北京呼吸医学研究所北京朝阳医院呼吸与危重症医学科,北京 100016
- 折叠
摘要
目的 探讨体液免疫水平与成人斯蒂尔病患者住院次数的相关性.方法 根据住院次数将57例病情活动期斯蒂尔病患者分为两组,运用酶联免疫吸附试验(ELISA)来对血清免疫球蛋白、补体水平IgA、IgM、IgG等水平进行检测.结果 57例AOSD患者被分为未再人院组(N=1,n=26)和再人院组(N＞1,n=31).N＞1组的IgA水平低于N=1组.IgA水平与住院次数呈负相关,r=-0.436,P=0.002.结论 血清IgA水平与斯蒂尔病患者住院次数呈负相关,血清IgA降低是成人斯蒂尔病复发相关的危险因素.
Abstract
Objective To investigate the correlation between humoral immune levels and the number of hospitalizations in adult Still's disease patients.Methods 57 active stage adult-onset Still's disease(AOSD)patients were divided into two groups based on the number of hospitalizations,and levels of immunoglobulin,complement,IgA,IgM,IgG were detected using enzyme-linked immunosorbent assay(ELISA).Results 57 AOSD patients were divided into a non-readmission group(N=1,n=26)and a readmission group(N＞1,n=31).The IgA level in group N＞1 was lower than group N=1.The IgA level was negatively correlated with the number of hospitalizations(r=-0.436,P=0.002).Conclusion The serum IgA level is negatively correlated with the number of hospitalizations,and reduced serum IgA is a risk factor for the recurrence of AOSD.
关键词
成人斯蒂尔病/免疫球蛋白A/补体/再住院Key words
Adult Still's disease/Immunoglobulin A/Complement/Readmission引用本文复制引用
出版年
2024
NETL
NSTL
万方数据