A Correlation Analysis of MHR,PLR,Blood Pressure Variability and Carotid Atherosclerosis in Hypertensive Patients
Objective To investigate the correlation between peripheral blood monocyte count/high-density lipoprotein ratio(MHR),platelet/lymphocyte ratio(PLR)and blood pressure variability and carotid atherosclerosis(CAS)in hypertensive patients.Methods 230 patients with essential hypertension admitted to our hospital from February,2021 to August,2022 were selected for the study.Carotid artery ultrasonography was performed among all patients.Patients with detected CAS plaque formation were included in the CAS group,while those without sclerosis were included in the non-CAS group.Values of MHR,PLR and coefficient of variation of 24h systolic blood pressure and 24h diastolic blood pressure were calculated for all subjects.General data,MHR,PLR and blood pressure variability were compared between sclerotic and non-sclerotic groups.The diagnostic value of MHR,PLR and blood pressure variability individually and in combination for CAS in essential hypertension was evaluated by ROC curve.The correlation between MHR,PLR,blood pressure variability and essential hypertension CAS was analyzed by Spearman method.Results Compared with non-CAS group,MHR,PLR and blood pressure variation coefficient(coefficient of variation of 24h systolic blood pressure and 24h diastolic blood pressure)in CAS group were significantly higher(P＜0.05).ROC curve showed that the combination of MHR,PLR and blood pressure variation coefficient(coefficient of variation of 24h systolic blood pressure and 24h diastolic blood pressure)had a high diagnostic value in detecting CAS in hypertension,with an AUC of 0.906,along with high sensitivity(89.00％)and specificity(85.00％).Spearman correlation results showed that MHR,PLR and coefficient of variation of 24h systolic blood pressure and 24h diastolic blood pressure were significantly positively correlated with CAS in essential hypertension patients(all P＜0.001).Conclusion For hypertensive patients with CAS,Values of MHR,PLR and coefficient of variation of 24h systolic blood pressure and 24h diastolic blood pressure are all high.The combined detection has a high diagnostic value,and there is a significant correlation between each index and the disease occurrence,which can provide an early diagnosis scheme for clinical essential hypertension patients with CAS.
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