The Relationship Between Interleukin-8 Gene rs4073 Polymorphism,Fibrinolytic System Activity and Neonatal Sepsis
Objective To explore the relationship between interleukin-8 gene rs4073 polymorphism,fibrinolytic system activity and neonatal sepsis.Methods Ninety-two neonates with sepsis admitted to the Neonatal Department in our hospital from January,2021 to January,2023 were selected as the study group(n=92),while 92 healthy neonates during the same period were selected as the control group(n=92).The general data of all subjects were collected and levels of C-reactive protein(CRP),antithrombin(AT),D-dimer(D-D)and platelet(PLT)in blood samples of these two groups were compared.The pathogen species of neonates with sepsis and IL-8 gene rs4073 polymorphism were identified and levels of pathogen species,serum indicators and coagulation indicators among different IL-8 genotypes were compared and evaluated.Results Levels of CRP,IL-6 and D-D in the study group were significantly higher than those in the control group,while levels of AT and PLT were significantly lower than those in the control group.The results of pathogen identification showed that Gram-positive bacteria were the main cause of sepsis in neonates,accounting for about 70％of the total cases.The distribution of IL-8 gene rs4073 genotypes in the study group was significantly different from that in the control group,and the gene frequency of allele T increased.There were significant differences in levels of serum indicators and coagulation indicators among different IL-8 gene rs4073 genotypes,among which levels of CRP,IL-6 and D-D in neonates with sepsis and TT genotype were significantly higher than those in other genotypes,while levels of PLT and AT were significantly lower than those in other genotypes(P＜0.05).Conclusion IL-8 gene rs4073 polymorphism is closely related to the occurrence of sepsis,and could participate in the pathogenesis of sepsis by affecting the activity of fibrinolytic and coagulation systems.
IL-8MutationPolymorphismNeonatal sepsisFibrinolytic systemCoagulation function
NETL
NSTL
万方数据
