术前三酰甘油、超氧化物歧化酶和细胞角蛋白19片段水平对非小细胞肺癌及肺良性结节的鉴别诊断价值
The Value of the Differential Diagnosis of Preoperative Triglyceride,Superoxide Dismutase and Cytokeratin 19 Fragment Levels in Non-small Cell Lung Cancer and Benign Lung Nodules
石纯倩 1冯杰 2张旭 2高艳红2
作者信息
- 1. 解放军总医院第一医学中心医学检验科,北京 100853;华北医疗健康集团邢台总医院医学检验科,河北邢台 054000
- 2. 解放军总医院第一医学中心医学检验科,北京 100853
- 折叠
摘要
目的 探讨术前三酰甘油(triglyceride,TG)、超氧化物歧化酶(superoxide dismutase,SOD)和细胞角蛋白19片段(cytokeratin 19-fragments,CYFRA21-1)对非小细胞肺癌(non small cell lung cancer,NSCLC)与肺 良性结节的鉴别诊断价值.方法 收集2022年10月至2023年10月在解放军总医院第一医学中心手术治疗的非小细胞肺癌患者105例、肺良性结节患者84例的临床资料,对患者基本信息及血清相关指标进行统计分析.结果 NSCLC组的TG水平低于良性结节组(Z=-2.295,P=0.022),SOD、CYFRA21-1 水平高于良性结节组(Z=-3.298、-2.611,P=0.001、0.009).二元Logistic回归分析结果显示,低水平TG对NSCLC的预测优于良性结节组(OR=0.557),SOD、CYFRA21-1是NSCLC发生的独立危险因素(P＜0.05),OR值分别为1.054、1.850.ROC曲线分析显示,TG、SOD、CYFRA21-1鉴别诊断两者的灵敏度分别为 0.762、0.448、0.419,特异性分别为 0.389、0.815、0.796,ROC 曲线下面积(AUC)分别为 0.549、0.653、0.619,3者联合检测灵敏度、特异性、AUC分别为0.657、0.815、0.763.结论 联合检测术前血清TG、SOD和CYFRA21-1,可以提高NSCLC与良性结节鉴别诊断的灵敏度及特异性.
Abstract
Objective To investigate the preoperative values of triglyceride(TG),superoxide dismutase(SOD)and cytokeratin 19-fragments(CYFRA21-1)in the differential diagnosis of non-small cell lung cancer(NSCLC)and benign lung nodules.Methods Clinical data of 105 patients with non-small cell lung cancer and 84 patients with benign lung nodules who were operated and treated at the First Medical Center of the General Hospital of the People's Liberation Army(PLA)from October,2022 to October,2023 were collected for this study.Patients'basic information,pathological reports and serum-related indexes were statistically analyzed.Results The level of TG in the NSCLC group was lower than that in the benign nodule group(Z=-2.295,P=0.022),while levels of SOD and CYFRA21-1 were higher than those in the benign nodule group(Z=-3.298,-2.611;P=0.001,0.009).ROC curve showed that the sensitivities for differential diagnosis of the two of TG,SOD and CYFRA21-1 were 0.762,0.448,and 0.419,respectively,while specificities were 0.389,0.815,and 0.796,respectively.The area under the ROC curve(AUC)were 0.549,0.653,and 0.619,respectively.The sensitivity,specificity,and AUC of the three-marker combination assays were 0.657,0.815,and 0.763,respectively.Conclusion Combined detection of preoperative serum TG,SOD,and CYFRA21-1 can improve the sensitivity and specificity in the differential diagnosis of non-small-cell lung cancer and benign nodules.
关键词
非小细胞肺癌/肺良性结节/三酰甘油/超氧化物歧化酶/细胞角蛋白19片段Key words
Non-small cell lung cancer/Benign lung nodules/Triglycerides/Superoxide dismutase/Cytokeratin 19 fragment引用本文复制引用
基金项目
国家重点研发计划课题(2017YFF0205401)
出版年
2024
NETL
NSTL
万方数据