The Relationship Between IL-1β Expression and Cellular Immunity in Esophageal Cancer
Objective To investigate and evaluate the relationship between IL-1β expression and cellular immunity in esophageal cancer.Methods A total of 38 patients with esophageal cancer were enrolled for the current study;Serum IL-1β level and absolute value of CD4+/CD8+T cell were detected by flow cytometer in all patients.8 patients received PD-1 immunotherapy were enrolled;Serum IL-1β level were detected by ELISA.TIMER database was utilized to analyze the effect of IL-1β on the level of immune infiltration and immune related genes in esophageal cancer.Results There was a negative correlation between the IL-1β expression and the ratio of CD4+/CD8+T cell(P=0.047);Serum IL-1β level was significantly descended after PD-1 immunotherapy(P=0.038);There was a negative correlation between the IL-1β expression and immune infiltration of macrophages(P=0.00241),while positively correlated with neutrophil infiltration(P=0.00324);The IL-1β expression was positively correlated with the expression of B2M(P=0.0128)and PD-L1(P=0.00174),but negatively correlated with the expression of TNFRSF13C(P=0.0094).Conclusion IL-1β negatively correlates with cellular immunity in esophageal cancer by suppressing immune infiltration.
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