BNP和WBC等多指标检测对急性脑梗死与脑出血鉴别诊断的临床应用价值研究
The Clinical Application Value of Multiple Indicators in the Differential Diagnosis of Acute Cerebral Infarction and Intracerebral Hemorrhage
陈彤岩 1史一君 1姜文灿 1王冬至 1郑光辉1
作者信息
- 1. 首都医科大学附属北京天坛医院实验诊断中心,北京 100070
- 折叠
摘要
目的 探讨血浆B型钠尿肽(BNP)和血液白细胞计数(WBC)等多项实验室常规检查对急性脑梗死与脑出血鉴别诊断的临床应用价值.方法 回顾性分析2023年1月至2023年12月于首都医科大学附属北京天坛医院住院患者急性脑梗死(1083例)和脑出血(1136例)的9项相关实验室检测结果,通过统计分析,探究其在急性脑梗死与脑出血鉴别诊断方面的临床意义.结果 经单因素分析和多因素回归分析后显示,两组患者的BNP、WBC、凝血酶时间(TT)、血清葡萄糖(GLU)、天门冬氨酸氨基转移酶(AST)、肌酐(CREA)差异均有统计学意义(P值均＜0.05),并进行联合诊断模型的构建,其诊断AUC=0.734,灵敏度为 66.9％,特异性为 68.9％,诊断模型为:Y=-0.002 × BNP+0.203 × WBC-0.032 × TT-0.030 × GLU+0.012 × AST+0.004× CREA-1.419.结论 联合BNP与WBC等多指标可有效地对急性脑梗死和脑出血进行鉴别诊断.
Abstract
Objective To investigate the clinical application value of multiple factors,including plasma B-type natriuretic peptide(BNP)and blood white blood cell count(WBC),in the differential diagnosis of acute cerebral infarction and intracerebral hemorrhage.Methods The results of 9 related laboratory tests of acute cerebral infarction(1083 cases)and intracerebral hemorrhage(1136 cases)in hospitalized patients in Beijing Tiantan Hospital,Capital Medical University from January,2023 to December,2023 were retrospectively analyzed.The clinical significance of these factors in the differential diagnosis of acute cerebral infarction and intracerebral hemorrhage was explored through statistical analysis.Results Univariate analysis showed that there were significant differences in BNP,WBC,thrombin time(TT),serum glucose(GLU),aspartate aminotransferase(AST)and creatinine(CREA)between the two groups(P＜0.05).The joint-diagnostic model was constructed with following results:diagnostic AUC=0.734,sensitivity was 66.9％,and specificity was 68.9％.The diagnostic model was:Y=-0.002 × BN P+0.203 × WBC-0.032 × TT-0.030 × GLU+0.012 × AST+0.004 × CREA-1.419.Conclusion The combination of BNP and WBC test results can effectively diagnose acute cerebral infarction and intracerebral hemorrhage.
关键词
脑卒中/急性脑梗死/脑出血/BNP/WBCKey words
Stroke/Acute cerebral infarction/Cerebral hemorrhage/BNP/WBC引用本文复制引用
基金项目
国家卫生健康委医学人才培养计划(MTP2022A011)
出版年
2024
NETL
NSTL
万方数据