An Analysis of the Clinical Value of Autoantibodies in Autoimmune Encephalitis
Objective Systemic autoantibodies are important for the diagnosis of autoimmune diseases,but their roles in autoimmune encephalitis(AE)remain unclear as of today.The purpose of this study was to explore the clinical value of autoantibodies in autoimmune encephalitis.Methods The systemic autoantibodies of patients with anti-NMDAR encephalitis and other forms of autoimmune encephalitis were evaluated,and encephalitis patients were divided into anti-nuclear antibody(ANA)positive group and anti-nuclear antibody(ANA)negative group according to the status of autoantibodies.Results A total of 194 patients with AE were tested for antinuclear antibody spectrum.The results showed that the overall positive rate of autoantibodies in AE was 35.10％,and the positive rate of antibodies in 70 patients with anti-NMDAR encephalitis was 32.86％,which was significantly higher than that in 49 patients with anti-LGI1 encephalitis(26.53％).The low titer ANA fluorescent karyotype was common,and the fluorescent karyotype was mainly nuclear granular type;There was a statistically significant difference in the titer of serum neuron antibody among different groups of ANA(P=0.032),indicating that there was an interaction between serum autoantibody and serum neuron antibody.Conclusion Autoantibodies are of great significance in the detection of patients with autoimmune encephalitis.Positive autoantibodies might cause immune dysfunction of the brain by interacting with antibodies against neuronal surface antigens.Common autoantibodies and even fluorescent karyotypes could provide important references for the initial diagnosis and treatment.
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