The Application of Serum NSE in the Early Diagnosis and Prognosis Assessment of Patients with Severe Infections in Emergency Departments
Objective To evaluate the application of NSE in the early detection and prediction of outcomes in 145 emergency patients with severe infection.Methods From June,2022 to June,2023,a total of 145 patients were enrolled in the study,including 120 with severe infections and 25 with common infections.Patient data on general conditions,changes in serum NSE levels,1L-6 levels,lactate content,oxygenation index ratio,APACHE Ⅱ evaluation,SOFA score,complications and prognosis were collected and analyzed.Results Among the 139 patients(95.86％)with underlying diseases,hypertension was the most common type(36 cases,24.8％),followed by diabetes(26 cases,17.9％),and coronary heart disease(21 cases,14.48％).Compared with the control group,serum levels of NSE and IL-6 were significantly higher in patients with severe infection(P＜0.01).Spearman rank correlation analysis showed a negative correlation between NSE level and GCS score in patients with severe infection.Kaplan-Meier(KM)survival analysis found that patients with low NSE levels had higher cumulative survival than patients with high NSE levels.The AUC for prognosis diagnosis of patients with severe infection was 0.710 when NSE≥13ng/mL.Conclusion This study demonstrates a significant increase in serum NSE levels in patients with severe infections,which can effectively assess their prognosis.
NSESevere infectionPrognosisK-M survival analysisEmergency department ICU
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